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A comparative study of target volumes based on (18)F-FDG PET-CT and ten phases of 4DCT for primary thoracic squamous esophageal cancer
PURPOSE: To investigate the correlations in target volumes based on (18)F-FDG PET/CT and four-dimensional CT (4DCT) to detect the feasibility of implementing PET in determining gross target volumes (GTV) for tumor motion for primary thoracic esophageal cancer (EC). METHODS: Thirty-three patients wit...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5229170/ https://www.ncbi.nlm.nih.gov/pubmed/28123302 http://dx.doi.org/10.2147/OTT.S95322 |
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author | Guo, Yanluan Li, Jianbin Zhang, Peng Zhang, Yingjie |
author_facet | Guo, Yanluan Li, Jianbin Zhang, Peng Zhang, Yingjie |
author_sort | Guo, Yanluan |
collection | PubMed |
description | PURPOSE: To investigate the correlations in target volumes based on (18)F-FDG PET/CT and four-dimensional CT (4DCT) to detect the feasibility of implementing PET in determining gross target volumes (GTV) for tumor motion for primary thoracic esophageal cancer (EC). METHODS: Thirty-three patients with EC sequentially underwent contrast-enhanced 3DCT, 4DCT, and (18)F-FDG PET-CT thoracic simulation. The internal gross target volume (IGTV)(10) was obtained by combining the GTV from ten phases of 4DCT. The GTVs based on PET/CT images were defined by setting of different standardized uptake value thresholds and visual contouring. The difference in volume ratio, conformity index (CI), and degree of inclusion (DI) between IGTV(10) and GTV(PET) was compared. RESULTS: The images from 20 patients were suitable for further analysis. The optimal volume ratio of 0.95±0.32, 1.06±0.50, 1.07±0.49 was at standardized uptake value (SUV)(2.5), SUV(20%), or manual contouring. The mean CIs were from 0.33 to 0.54. The best CIs were at SUV(2.0) (0.51±0.11), SUV(2.5) (0.53±0.13), SUV(20%) (0.53±0.12), and manual contouring (0.54±0.14). The mean DIs of GTV(PET) in IGTV(10) were from 0.60 to 0.90, and the mean DIs of IGTV(10) in GTV(PET) ranged from 0.35 to 0.78. A negative correlation was found between the mean CI and different SUV (P=0.000). CONCLUSION: None of the PET-based contours had both close spatial and volumetric approximation to the 4DCT IGTV(10). Further evaluation and optimization of PET as a tool for target identification are required. |
format | Online Article Text |
id | pubmed-5229170 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-52291702017-01-25 A comparative study of target volumes based on (18)F-FDG PET-CT and ten phases of 4DCT for primary thoracic squamous esophageal cancer Guo, Yanluan Li, Jianbin Zhang, Peng Zhang, Yingjie Onco Targets Ther Original Research PURPOSE: To investigate the correlations in target volumes based on (18)F-FDG PET/CT and four-dimensional CT (4DCT) to detect the feasibility of implementing PET in determining gross target volumes (GTV) for tumor motion for primary thoracic esophageal cancer (EC). METHODS: Thirty-three patients with EC sequentially underwent contrast-enhanced 3DCT, 4DCT, and (18)F-FDG PET-CT thoracic simulation. The internal gross target volume (IGTV)(10) was obtained by combining the GTV from ten phases of 4DCT. The GTVs based on PET/CT images were defined by setting of different standardized uptake value thresholds and visual contouring. The difference in volume ratio, conformity index (CI), and degree of inclusion (DI) between IGTV(10) and GTV(PET) was compared. RESULTS: The images from 20 patients were suitable for further analysis. The optimal volume ratio of 0.95±0.32, 1.06±0.50, 1.07±0.49 was at standardized uptake value (SUV)(2.5), SUV(20%), or manual contouring. The mean CIs were from 0.33 to 0.54. The best CIs were at SUV(2.0) (0.51±0.11), SUV(2.5) (0.53±0.13), SUV(20%) (0.53±0.12), and manual contouring (0.54±0.14). The mean DIs of GTV(PET) in IGTV(10) were from 0.60 to 0.90, and the mean DIs of IGTV(10) in GTV(PET) ranged from 0.35 to 0.78. A negative correlation was found between the mean CI and different SUV (P=0.000). CONCLUSION: None of the PET-based contours had both close spatial and volumetric approximation to the 4DCT IGTV(10). Further evaluation and optimization of PET as a tool for target identification are required. Dove Medical Press 2017-01-06 /pmc/articles/PMC5229170/ /pubmed/28123302 http://dx.doi.org/10.2147/OTT.S95322 Text en © 2017 Guo et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Guo, Yanluan Li, Jianbin Zhang, Peng Zhang, Yingjie A comparative study of target volumes based on (18)F-FDG PET-CT and ten phases of 4DCT for primary thoracic squamous esophageal cancer |
title | A comparative study of target volumes based on (18)F-FDG PET-CT and ten phases of 4DCT for primary thoracic squamous esophageal cancer |
title_full | A comparative study of target volumes based on (18)F-FDG PET-CT and ten phases of 4DCT for primary thoracic squamous esophageal cancer |
title_fullStr | A comparative study of target volumes based on (18)F-FDG PET-CT and ten phases of 4DCT for primary thoracic squamous esophageal cancer |
title_full_unstemmed | A comparative study of target volumes based on (18)F-FDG PET-CT and ten phases of 4DCT for primary thoracic squamous esophageal cancer |
title_short | A comparative study of target volumes based on (18)F-FDG PET-CT and ten phases of 4DCT for primary thoracic squamous esophageal cancer |
title_sort | comparative study of target volumes based on (18)f-fdg pet-ct and ten phases of 4dct for primary thoracic squamous esophageal cancer |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5229170/ https://www.ncbi.nlm.nih.gov/pubmed/28123302 http://dx.doi.org/10.2147/OTT.S95322 |
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