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A comparative study of target volumes based on (18)F-FDG PET-CT and ten phases of 4DCT for primary thoracic squamous esophageal cancer

PURPOSE: To investigate the correlations in target volumes based on (18)F-FDG PET/CT and four-dimensional CT (4DCT) to detect the feasibility of implementing PET in determining gross target volumes (GTV) for tumor motion for primary thoracic esophageal cancer (EC). METHODS: Thirty-three patients wit...

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Autores principales: Guo, Yanluan, Li, Jianbin, Zhang, Peng, Zhang, Yingjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5229170/
https://www.ncbi.nlm.nih.gov/pubmed/28123302
http://dx.doi.org/10.2147/OTT.S95322
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author Guo, Yanluan
Li, Jianbin
Zhang, Peng
Zhang, Yingjie
author_facet Guo, Yanluan
Li, Jianbin
Zhang, Peng
Zhang, Yingjie
author_sort Guo, Yanluan
collection PubMed
description PURPOSE: To investigate the correlations in target volumes based on (18)F-FDG PET/CT and four-dimensional CT (4DCT) to detect the feasibility of implementing PET in determining gross target volumes (GTV) for tumor motion for primary thoracic esophageal cancer (EC). METHODS: Thirty-three patients with EC sequentially underwent contrast-enhanced 3DCT, 4DCT, and (18)F-FDG PET-CT thoracic simulation. The internal gross target volume (IGTV)(10) was obtained by combining the GTV from ten phases of 4DCT. The GTVs based on PET/CT images were defined by setting of different standardized uptake value thresholds and visual contouring. The difference in volume ratio, conformity index (CI), and degree of inclusion (DI) between IGTV(10) and GTV(PET) was compared. RESULTS: The images from 20 patients were suitable for further analysis. The optimal volume ratio of 0.95±0.32, 1.06±0.50, 1.07±0.49 was at standardized uptake value (SUV)(2.5), SUV(20%), or manual contouring. The mean CIs were from 0.33 to 0.54. The best CIs were at SUV(2.0) (0.51±0.11), SUV(2.5) (0.53±0.13), SUV(20%) (0.53±0.12), and manual contouring (0.54±0.14). The mean DIs of GTV(PET) in IGTV(10) were from 0.60 to 0.90, and the mean DIs of IGTV(10) in GTV(PET) ranged from 0.35 to 0.78. A negative correlation was found between the mean CI and different SUV (P=0.000). CONCLUSION: None of the PET-based contours had both close spatial and volumetric approximation to the 4DCT IGTV(10). Further evaluation and optimization of PET as a tool for target identification are required.
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spelling pubmed-52291702017-01-25 A comparative study of target volumes based on (18)F-FDG PET-CT and ten phases of 4DCT for primary thoracic squamous esophageal cancer Guo, Yanluan Li, Jianbin Zhang, Peng Zhang, Yingjie Onco Targets Ther Original Research PURPOSE: To investigate the correlations in target volumes based on (18)F-FDG PET/CT and four-dimensional CT (4DCT) to detect the feasibility of implementing PET in determining gross target volumes (GTV) for tumor motion for primary thoracic esophageal cancer (EC). METHODS: Thirty-three patients with EC sequentially underwent contrast-enhanced 3DCT, 4DCT, and (18)F-FDG PET-CT thoracic simulation. The internal gross target volume (IGTV)(10) was obtained by combining the GTV from ten phases of 4DCT. The GTVs based on PET/CT images were defined by setting of different standardized uptake value thresholds and visual contouring. The difference in volume ratio, conformity index (CI), and degree of inclusion (DI) between IGTV(10) and GTV(PET) was compared. RESULTS: The images from 20 patients were suitable for further analysis. The optimal volume ratio of 0.95±0.32, 1.06±0.50, 1.07±0.49 was at standardized uptake value (SUV)(2.5), SUV(20%), or manual contouring. The mean CIs were from 0.33 to 0.54. The best CIs were at SUV(2.0) (0.51±0.11), SUV(2.5) (0.53±0.13), SUV(20%) (0.53±0.12), and manual contouring (0.54±0.14). The mean DIs of GTV(PET) in IGTV(10) were from 0.60 to 0.90, and the mean DIs of IGTV(10) in GTV(PET) ranged from 0.35 to 0.78. A negative correlation was found between the mean CI and different SUV (P=0.000). CONCLUSION: None of the PET-based contours had both close spatial and volumetric approximation to the 4DCT IGTV(10). Further evaluation and optimization of PET as a tool for target identification are required. Dove Medical Press 2017-01-06 /pmc/articles/PMC5229170/ /pubmed/28123302 http://dx.doi.org/10.2147/OTT.S95322 Text en © 2017 Guo et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Guo, Yanluan
Li, Jianbin
Zhang, Peng
Zhang, Yingjie
A comparative study of target volumes based on (18)F-FDG PET-CT and ten phases of 4DCT for primary thoracic squamous esophageal cancer
title A comparative study of target volumes based on (18)F-FDG PET-CT and ten phases of 4DCT for primary thoracic squamous esophageal cancer
title_full A comparative study of target volumes based on (18)F-FDG PET-CT and ten phases of 4DCT for primary thoracic squamous esophageal cancer
title_fullStr A comparative study of target volumes based on (18)F-FDG PET-CT and ten phases of 4DCT for primary thoracic squamous esophageal cancer
title_full_unstemmed A comparative study of target volumes based on (18)F-FDG PET-CT and ten phases of 4DCT for primary thoracic squamous esophageal cancer
title_short A comparative study of target volumes based on (18)F-FDG PET-CT and ten phases of 4DCT for primary thoracic squamous esophageal cancer
title_sort comparative study of target volumes based on (18)f-fdg pet-ct and ten phases of 4dct for primary thoracic squamous esophageal cancer
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5229170/
https://www.ncbi.nlm.nih.gov/pubmed/28123302
http://dx.doi.org/10.2147/OTT.S95322
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