Single Nucleotide Variants of Candidate Genes in Aggrecan Metabolic Pathway Are Associated with Lumbar Disc Degeneration and Modic Changes

INTRODUCTION: Lumbar disc degeneration (LDD) is genetically determined and severity of LDD is associated with Modic changes. Aggrecan is a major proteoglycan in the intervertebral disc and end plate. Progressive reduction of aggrecan is a main feature of LDD and Modic changes. OBJECTIVES: The study...

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Detalles Bibliográficos
Autores principales: Perera, Romain Shanil, Dissanayake, Poruwalage Harsha, Senarath, Upul, Wijayaratne, Lalith Sirimevan, Karunanayake, Aranjan Lional, Dissanayake, Vajira Harshadeva Weerabaddana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5231268/
https://www.ncbi.nlm.nih.gov/pubmed/28081267
http://dx.doi.org/10.1371/journal.pone.0169835

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