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Maternal Supply of Cas9 to Zygotes Facilitates the Efficient Generation of Site-Specific Mutant Mouse Models

Genome manipulation in the mouse via microinjection of CRISPR/Cas9 site-specific nucleases has allowed the production time for genetically modified mouse models to be significantly reduced. Successful genome manipulation in the mouse has already been reported using Cas9 supplied by microinjection of...

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Detalles Bibliográficos
Autores principales:	Cebrian-Serrano, Alberto, Zha, Shijun, Hanssen, Lars, Biggs, Daniel, Preece, Christopher, Davies, Benjamin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5231326/ https://www.ncbi.nlm.nih.gov/pubmed/28081254 http://dx.doi.org/10.1371/journal.pone.0169887

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