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AT7867 Inhibits Human Colorectal Cancer Cells via AKT-Dependent and AKT-Independent Mechanisms

AKT is often hyper-activated in human colorectal cancers (CRC). This current study evaluated the potential anti-CRC activity by AT7867, a novel AKT and p70S6K1 (S6K1) dual inhibitor. We showed that AT7867 inhibited survival and proliferation of established (HT-29, HCT116 and DLD-1 lines) and primary...

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Detalles Bibliográficos
Autores principales:	Zhang, Shihu, Deng, Zhengming, Yao, Chen, Huang, Ping, Zhang, Yi, Cao, Shibing, Li, Xiangcheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5231330/ https://www.ncbi.nlm.nih.gov/pubmed/28081222 http://dx.doi.org/10.1371/journal.pone.0169585

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