Soluble Egg Antigens of Schistosoma japonicum Induce Senescence of Activated Hepatic Stellate Cells by Activation of the FoxO3a/SKP2/P27 Pathway

BACKGROUND: Liver fibrosis was viewed as a reversible process. The activation of hepatic stellate cells (HSCs) is a key event in the process of liver fibrosis. The induction of senescence of HSCs would accelerate the clearance of the activated HSCs. Previously, we demonstrated that soluble egg antig...

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Detalles Bibliográficos
Autores principales: Duan, Yinong, Pan, Jing, Chen, Jinling, Zhu, Dandan, Wang, Jianxin, Sun, Xiaolei, Chen, Liuting, Wu, Liting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5231384/
https://www.ncbi.nlm.nih.gov/pubmed/28036393
http://dx.doi.org/10.1371/journal.pntd.0005268

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