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Multivalent Rab interactions determine tether-mediated membrane fusion

Membrane fusion at endomembranes requires cross-talk between Rab GTPases and tethers to drive SNARE-mediated lipid bilayer mixing. Several tethers have multiple Rab-binding sites with largely untested function. Here we dissected the lysosomal HOPS complex as a tethering complex with just two binding...

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Detalles Bibliográficos
Autores principales:	Lürick, Anna, Gao, Jieqiong, Kuhlee, Anne, Yavavli, Erdal, Langemeyer, Lars, Perz, Angela, Raunser, Stefan, Ungermann, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2017
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5231900/ https://www.ncbi.nlm.nih.gov/pubmed/27852901 http://dx.doi.org/10.1091/mbc.E16-11-0764

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