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Structural Variation in Amyloid-β Fibrils from Alzheimer’s Disease Clinical Subtypes

Aggregation of amyloid-β (Aβ) peptides into fibrils or other self-assembled states is central to Alzheimer’s disease (AD) pathogenesis. Fibrils formed in vitro by 40- and 42-residue Aβ peptides (Aβ40 and Aβ42) are polymorphic, with variations in molecular structure that depend on fibril growth condi...

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Detalles Bibliográficos
Autores principales:	Qiang, Wei, Yau, Wai-Ming, Lu, Jun-Xia, Collinge, John, Tycko, Robert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5233555/ https://www.ncbi.nlm.nih.gov/pubmed/28052060 http://dx.doi.org/10.1038/nature20814

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