Omic studies reveal the pathogenic lipid droplet proteins in non-alcoholic fatty liver disease

Non-alcoholic fatty liver disease (NAFLD) is an epidemic metabolic condition driven by an underlying lipid homeostasis disorder. The lipid droplet (LD), the main organelle involved in neutral lipid storage and hydrolysis, is a potential target for NAFLD therapeutic treatment. In this review, we summ...

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Detalles Bibliográficos
Autores principales: Zhang, Xuelin, Wang, Yang, Liu, Pingsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Higher Education Press 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5233612/
https://www.ncbi.nlm.nih.gov/pubmed/27757845
http://dx.doi.org/10.1007/s13238-016-0327-9
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author Zhang, Xuelin
Wang, Yang
Liu, Pingsheng
author_facet Zhang, Xuelin
Wang, Yang
Liu, Pingsheng
author_sort Zhang, Xuelin
collection PubMed
description Non-alcoholic fatty liver disease (NAFLD) is an epidemic metabolic condition driven by an underlying lipid homeostasis disorder. The lipid droplet (LD), the main organelle involved in neutral lipid storage and hydrolysis, is a potential target for NAFLD therapeutic treatment. In this review, we summarize recent progress elucidating the connections between LD-associated proteins and NAFLD found by genome-wide association studies (GWAS), genomic and proteomic studies. Finally, we discuss a possible mechanism by which the protein 17β-hydroxysteroid dehydrogenase 13 (17β-HSD13) may promote the development of NAFLD.
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spelling pubmed-52336122017-01-25 Omic studies reveal the pathogenic lipid droplet proteins in non-alcoholic fatty liver disease Zhang, Xuelin Wang, Yang Liu, Pingsheng Protein Cell Review Non-alcoholic fatty liver disease (NAFLD) is an epidemic metabolic condition driven by an underlying lipid homeostasis disorder. The lipid droplet (LD), the main organelle involved in neutral lipid storage and hydrolysis, is a potential target for NAFLD therapeutic treatment. In this review, we summarize recent progress elucidating the connections between LD-associated proteins and NAFLD found by genome-wide association studies (GWAS), genomic and proteomic studies. Finally, we discuss a possible mechanism by which the protein 17β-hydroxysteroid dehydrogenase 13 (17β-HSD13) may promote the development of NAFLD. Higher Education Press 2016-10-18 2017-01 /pmc/articles/PMC5233612/ /pubmed/27757845 http://dx.doi.org/10.1007/s13238-016-0327-9 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Zhang, Xuelin
Wang, Yang
Liu, Pingsheng
Omic studies reveal the pathogenic lipid droplet proteins in non-alcoholic fatty liver disease
title Omic studies reveal the pathogenic lipid droplet proteins in non-alcoholic fatty liver disease
title_full Omic studies reveal the pathogenic lipid droplet proteins in non-alcoholic fatty liver disease
title_fullStr Omic studies reveal the pathogenic lipid droplet proteins in non-alcoholic fatty liver disease
title_full_unstemmed Omic studies reveal the pathogenic lipid droplet proteins in non-alcoholic fatty liver disease
title_short Omic studies reveal the pathogenic lipid droplet proteins in non-alcoholic fatty liver disease
title_sort omic studies reveal the pathogenic lipid droplet proteins in non-alcoholic fatty liver disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5233612/
https://www.ncbi.nlm.nih.gov/pubmed/27757845
http://dx.doi.org/10.1007/s13238-016-0327-9
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AT liupingsheng omicstudiesrevealthepathogeniclipiddropletproteinsinnonalcoholicfattyliverdisease

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