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Pattern of Reduced Functional Connectivity and Structural Abnormalities in Parkinson’s Disease: An Exploratory Study
BACKGROUND: MRI brain changes in Parkinson’s disease (PD) are controversial. OBJECTIVES: We aimed to describe structural and functional changes in PD. METHODS: Sixty-six patients with PD (57.94 ± 10.25 years) diagnosed according to the UK Brain Bank criteria were included. We performed a whole brain...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5233672/ https://www.ncbi.nlm.nih.gov/pubmed/28133455 http://dx.doi.org/10.3389/fneur.2016.00243 |
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author | Guimarães, Rachel Paes Arci Santos, Maria Cristina Dagher, Alain Campos, Lidiane Soares Azevedo, Paula Piovesana, Luiza Gonzaga De Campos, Brunno Machado Larcher, Kevin Zeighami, Yashar Scarparo Amato-Filho, Augusto C. Cendes, Fernando D’Abreu, Anelyssa Cysne Frota |
author_facet | Guimarães, Rachel Paes Arci Santos, Maria Cristina Dagher, Alain Campos, Lidiane Soares Azevedo, Paula Piovesana, Luiza Gonzaga De Campos, Brunno Machado Larcher, Kevin Zeighami, Yashar Scarparo Amato-Filho, Augusto C. Cendes, Fernando D’Abreu, Anelyssa Cysne Frota |
author_sort | Guimarães, Rachel Paes |
collection | PubMed |
description | BACKGROUND: MRI brain changes in Parkinson’s disease (PD) are controversial. OBJECTIVES: We aimed to describe structural and functional changes in PD. METHODS: Sixty-six patients with PD (57.94 ± 10.25 years) diagnosed according to the UK Brain Bank criteria were included. We performed a whole brain analysis using voxel-based morphometry (VBM–SPM 8 software), cortical thickness (CT) using CIVET, and resting-state fMRI using the Neuroimaging Analysis Kit software to compare patients and controls. For VBM and CT we classified subjects into three groups according to disease severity: mild PD [Hoehn and Yahr scale (HY) 1–1.5], moderate PD (HY 2–2.5), and severe PD (HY 3–5). RESULTS: We observed gray matter atrophy in the insula and inferior frontal gyrus in the moderate PD and in the insula, frontal gyrus, putamen, cingulated, and paracingulate gyri in the severe groups. In the CT analysis, in mild PD, cortical thinning was restricted to the superior temporal gyrus, gyrus rectus, and olfactory cortex; in the moderate group, the postcentral gyrus, supplementary motor area, and inferior frontal gyrus were also affected; in the severe PD, areas such as the precentral and postentral gyrus, temporal pole, fusiform, and occipital gyrus had reduced cortical thinning. We observed altered connectivity at the default mode, visual, sensorimotor, and cerebellar networks. CONCLUSION: Subjects with mild symptoms already have cortical involvement; however, further cerebral involvement seems to follow Braak’s proposed mechanism. Similar regions are affected both structurally and functionally. We believe the combination of different MRI techniques may be useful in evaluating progressive brain involvement and they may eventually be used as surrogate markers of disease progression. |
format | Online Article Text |
id | pubmed-5233672 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-52336722017-01-27 Pattern of Reduced Functional Connectivity and Structural Abnormalities in Parkinson’s Disease: An Exploratory Study Guimarães, Rachel Paes Arci Santos, Maria Cristina Dagher, Alain Campos, Lidiane Soares Azevedo, Paula Piovesana, Luiza Gonzaga De Campos, Brunno Machado Larcher, Kevin Zeighami, Yashar Scarparo Amato-Filho, Augusto C. Cendes, Fernando D’Abreu, Anelyssa Cysne Frota Front Neurol Neuroscience BACKGROUND: MRI brain changes in Parkinson’s disease (PD) are controversial. OBJECTIVES: We aimed to describe structural and functional changes in PD. METHODS: Sixty-six patients with PD (57.94 ± 10.25 years) diagnosed according to the UK Brain Bank criteria were included. We performed a whole brain analysis using voxel-based morphometry (VBM–SPM 8 software), cortical thickness (CT) using CIVET, and resting-state fMRI using the Neuroimaging Analysis Kit software to compare patients and controls. For VBM and CT we classified subjects into three groups according to disease severity: mild PD [Hoehn and Yahr scale (HY) 1–1.5], moderate PD (HY 2–2.5), and severe PD (HY 3–5). RESULTS: We observed gray matter atrophy in the insula and inferior frontal gyrus in the moderate PD and in the insula, frontal gyrus, putamen, cingulated, and paracingulate gyri in the severe groups. In the CT analysis, in mild PD, cortical thinning was restricted to the superior temporal gyrus, gyrus rectus, and olfactory cortex; in the moderate group, the postcentral gyrus, supplementary motor area, and inferior frontal gyrus were also affected; in the severe PD, areas such as the precentral and postentral gyrus, temporal pole, fusiform, and occipital gyrus had reduced cortical thinning. We observed altered connectivity at the default mode, visual, sensorimotor, and cerebellar networks. CONCLUSION: Subjects with mild symptoms already have cortical involvement; however, further cerebral involvement seems to follow Braak’s proposed mechanism. Similar regions are affected both structurally and functionally. We believe the combination of different MRI techniques may be useful in evaluating progressive brain involvement and they may eventually be used as surrogate markers of disease progression. Frontiers Media S.A. 2017-01-13 /pmc/articles/PMC5233672/ /pubmed/28133455 http://dx.doi.org/10.3389/fneur.2016.00243 Text en Copyright © 2017 Guimarães, Arci Santos, Dagher, Campos, Azevedo, Piovesana, De Campos, Larcher, Zeighami, Scarparo Amato-Filho, Cendes and D’Abreu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Guimarães, Rachel Paes Arci Santos, Maria Cristina Dagher, Alain Campos, Lidiane Soares Azevedo, Paula Piovesana, Luiza Gonzaga De Campos, Brunno Machado Larcher, Kevin Zeighami, Yashar Scarparo Amato-Filho, Augusto C. Cendes, Fernando D’Abreu, Anelyssa Cysne Frota Pattern of Reduced Functional Connectivity and Structural Abnormalities in Parkinson’s Disease: An Exploratory Study |
title | Pattern of Reduced Functional Connectivity and Structural Abnormalities in Parkinson’s Disease: An Exploratory Study |
title_full | Pattern of Reduced Functional Connectivity and Structural Abnormalities in Parkinson’s Disease: An Exploratory Study |
title_fullStr | Pattern of Reduced Functional Connectivity and Structural Abnormalities in Parkinson’s Disease: An Exploratory Study |
title_full_unstemmed | Pattern of Reduced Functional Connectivity and Structural Abnormalities in Parkinson’s Disease: An Exploratory Study |
title_short | Pattern of Reduced Functional Connectivity and Structural Abnormalities in Parkinson’s Disease: An Exploratory Study |
title_sort | pattern of reduced functional connectivity and structural abnormalities in parkinson’s disease: an exploratory study |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5233672/ https://www.ncbi.nlm.nih.gov/pubmed/28133455 http://dx.doi.org/10.3389/fneur.2016.00243 |
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