Cargando…

Parasite Infection, Carcinogenesis and Human Malignancy

Cancer may be induced by many environmental and physiological conditions. Infections with viruses, bacteria and parasites have been recognized for years to be associated with human carcinogenicity. Here we review current concepts of carcinogenicity and its associations with parasitic infections. The...

Descripción completa

Detalles Bibliográficos
Autores principales: van Tong, Hoang, Brindley, Paul J., Meyer, Christian G., Velavan, Thirumalaisamy P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5233816/
https://www.ncbi.nlm.nih.gov/pubmed/27956028
http://dx.doi.org/10.1016/j.ebiom.2016.11.034
_version_ 1782494899879280640
author van Tong, Hoang
Brindley, Paul J.
Meyer, Christian G.
Velavan, Thirumalaisamy P.
author_facet van Tong, Hoang
Brindley, Paul J.
Meyer, Christian G.
Velavan, Thirumalaisamy P.
author_sort van Tong, Hoang
collection PubMed
description Cancer may be induced by many environmental and physiological conditions. Infections with viruses, bacteria and parasites have been recognized for years to be associated with human carcinogenicity. Here we review current concepts of carcinogenicity and its associations with parasitic infections. The helminth diseases schistosomiasis, opisthorchiasis, and clonorchiasis are highly carcinogenic while the protozoan Trypanosoma cruzi, the causing agent of Chagas disease, has a dual role in the development of cancer, including both carcinogenic and anticancer properties. Although malaria per se does not appear to be causative in carcinogenesis, it is strongly associated with the occurrence of endemic Burkitt lymphoma in areas holoendemic for malaria. The initiation of Plasmodium falciparum related endemic Burkitt lymphoma requires additional transforming events induced by the Epstein-Barr virus. Observations suggest that Strongyloides stercoralis may be a relevant co-factor in HTLV-1-related T cell lymphomas. This review provides an overview of the mechanisms of parasitic infection-induced carcinogenicity.
format Online
Article
Text
id pubmed-5233816
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-52338162017-01-23 Parasite Infection, Carcinogenesis and Human Malignancy van Tong, Hoang Brindley, Paul J. Meyer, Christian G. Velavan, Thirumalaisamy P. EBioMedicine Review Cancer may be induced by many environmental and physiological conditions. Infections with viruses, bacteria and parasites have been recognized for years to be associated with human carcinogenicity. Here we review current concepts of carcinogenicity and its associations with parasitic infections. The helminth diseases schistosomiasis, opisthorchiasis, and clonorchiasis are highly carcinogenic while the protozoan Trypanosoma cruzi, the causing agent of Chagas disease, has a dual role in the development of cancer, including both carcinogenic and anticancer properties. Although malaria per se does not appear to be causative in carcinogenesis, it is strongly associated with the occurrence of endemic Burkitt lymphoma in areas holoendemic for malaria. The initiation of Plasmodium falciparum related endemic Burkitt lymphoma requires additional transforming events induced by the Epstein-Barr virus. Observations suggest that Strongyloides stercoralis may be a relevant co-factor in HTLV-1-related T cell lymphomas. This review provides an overview of the mechanisms of parasitic infection-induced carcinogenicity. Elsevier 2016-12-02 /pmc/articles/PMC5233816/ /pubmed/27956028 http://dx.doi.org/10.1016/j.ebiom.2016.11.034 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
van Tong, Hoang
Brindley, Paul J.
Meyer, Christian G.
Velavan, Thirumalaisamy P.
Parasite Infection, Carcinogenesis and Human Malignancy
title Parasite Infection, Carcinogenesis and Human Malignancy
title_full Parasite Infection, Carcinogenesis and Human Malignancy
title_fullStr Parasite Infection, Carcinogenesis and Human Malignancy
title_full_unstemmed Parasite Infection, Carcinogenesis and Human Malignancy
title_short Parasite Infection, Carcinogenesis and Human Malignancy
title_sort parasite infection, carcinogenesis and human malignancy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5233816/
https://www.ncbi.nlm.nih.gov/pubmed/27956028
http://dx.doi.org/10.1016/j.ebiom.2016.11.034
work_keys_str_mv AT vantonghoang parasiteinfectioncarcinogenesisandhumanmalignancy
AT brindleypaulj parasiteinfectioncarcinogenesisandhumanmalignancy
AT meyerchristiang parasiteinfectioncarcinogenesisandhumanmalignancy
AT velavanthirumalaisamyp parasiteinfectioncarcinogenesisandhumanmalignancy