Oncogenic KRas-induced Increase in Fluid-phase Endocytosis is Dependent on N-WASP and is Required for the Formation of Pancreatic Preneoplastic Lesions

Fluid-phase endocytosis is a homeostatic process with an unknown role in tumor initiation. The driver mutation in pancreatic ductal adenocarcinoma (PDAC) is constitutively active KRas(G12D), which induces neoplastic transformation of acinar cells through acinar-to-ductal metaplasia (ADM). We have pr...

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Detalles Bibliográficos
Autores principales: Lubeseder-Martellato, Clara, Alexandrow, Katharina, Hidalgo-Sastre, Ana, Heid, Irina, Boos, Sophie Luise, Briel, Thomas, Schmid, Roland M., Siveke, Jens T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5233824/
https://www.ncbi.nlm.nih.gov/pubmed/28057438
http://dx.doi.org/10.1016/j.ebiom.2016.12.013

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