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In vivo confocal microscopy of toxic keratopathy

PURPOSE: To explore the morphological characteristics of toxic keratopathy (TK), which clinically presented as superficial punctate keratopathy (SPK), with the application of in vivo laser-scanning confocal microscopy (LSCM), and evaluate its potential in the early diagnosis of TK. PATIENTS AND METH...

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Autores principales: Chen, Y, Le, Q, Hong, J, Gong, L, Xu, J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5233937/
https://www.ncbi.nlm.nih.gov/pubmed/27740620
http://dx.doi.org/10.1038/eye.2016.213
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author Chen, Y
Le, Q
Hong, J
Gong, L
Xu, J
author_facet Chen, Y
Le, Q
Hong, J
Gong, L
Xu, J
author_sort Chen, Y
collection PubMed
description PURPOSE: To explore the morphological characteristics of toxic keratopathy (TK), which clinically presented as superficial punctate keratopathy (SPK), with the application of in vivo laser-scanning confocal microscopy (LSCM), and evaluate its potential in the early diagnosis of TK. PATIENTS AND METHODS: This was a cross-sectional study involving 16 patients with TK and 16 patients with dry eye (DE), demonstrating SPK under slit-lamp observation, and 10 normal eyes were enrolled in the study. All participants underwent history interviews, fluorescein staining, tear film break-up time (BUT) tests, Schirmer tests, and in vivo LSCM. RESULTS: The area grading of corneal fluorescein punctate staining was higher in the TK group than the DE group. Measured by in vivo LSCM, superficial epithelial cell density was lower in the TK group than that of DE group. The sub-basal nerve presented lower density and tortuosity in the TK group than the DE group. Most notably, deposits with a snow-like appearance were observed in the epithelium in 12/16 (75.0%) of the TK cases, but none in the DE group (P<0.05). CONCLUSION: The SPK in TK patients was characterized by more widespread punctate staining, a lower density of superficial epithelial cells and sub-basal nerves, and a typical snow-like pattern of deposits in the epithelium by LSCM. These features might facilitate early diagnosis of TK from other disorders manifested as SPK.
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spelling pubmed-52339372017-01-24 In vivo confocal microscopy of toxic keratopathy Chen, Y Le, Q Hong, J Gong, L Xu, J Eye (Lond) Clinical Study PURPOSE: To explore the morphological characteristics of toxic keratopathy (TK), which clinically presented as superficial punctate keratopathy (SPK), with the application of in vivo laser-scanning confocal microscopy (LSCM), and evaluate its potential in the early diagnosis of TK. PATIENTS AND METHODS: This was a cross-sectional study involving 16 patients with TK and 16 patients with dry eye (DE), demonstrating SPK under slit-lamp observation, and 10 normal eyes were enrolled in the study. All participants underwent history interviews, fluorescein staining, tear film break-up time (BUT) tests, Schirmer tests, and in vivo LSCM. RESULTS: The area grading of corneal fluorescein punctate staining was higher in the TK group than the DE group. Measured by in vivo LSCM, superficial epithelial cell density was lower in the TK group than that of DE group. The sub-basal nerve presented lower density and tortuosity in the TK group than the DE group. Most notably, deposits with a snow-like appearance were observed in the epithelium in 12/16 (75.0%) of the TK cases, but none in the DE group (P<0.05). CONCLUSION: The SPK in TK patients was characterized by more widespread punctate staining, a lower density of superficial epithelial cells and sub-basal nerves, and a typical snow-like pattern of deposits in the epithelium by LSCM. These features might facilitate early diagnosis of TK from other disorders manifested as SPK. Nature Publishing Group 2017-01 2016-10-14 /pmc/articles/PMC5233937/ /pubmed/27740620 http://dx.doi.org/10.1038/eye.2016.213 Text en Copyright © 2017 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Clinical Study
Chen, Y
Le, Q
Hong, J
Gong, L
Xu, J
In vivo confocal microscopy of toxic keratopathy
title In vivo confocal microscopy of toxic keratopathy
title_full In vivo confocal microscopy of toxic keratopathy
title_fullStr In vivo confocal microscopy of toxic keratopathy
title_full_unstemmed In vivo confocal microscopy of toxic keratopathy
title_short In vivo confocal microscopy of toxic keratopathy
title_sort in vivo confocal microscopy of toxic keratopathy
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5233937/
https://www.ncbi.nlm.nih.gov/pubmed/27740620
http://dx.doi.org/10.1038/eye.2016.213
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