Cargando…

A Conditional Knockout Mouse Model Reveals a Critical Role of PKD1 in Osteoblast Differentiation and Bone Development

The protein kinase D family of serine/threonine kinases, particularly PKD1, has been implicated in the regulation of a complex array of fundamental biological processes. However, its function and mechanism underlying PKD1-mediated the bone development and osteoblast differentiation are not fully und...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Shao, Xu, Wanfu, Xing, Zhe, Qian, Jiabi, Chen, Liping, Gu, Ruonan, Guo, Wenjing, Lai, Xiaoju, Zhao, Wanlu, Li, Songyu, Wang, Yaodong, Wang, Q. Jane, Deng, Fan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5233966/ https://www.ncbi.nlm.nih.gov/pubmed/28084409 http://dx.doi.org/10.1038/srep40505

Ejemplares similares

Pyruvate Kinase M2 Promotes Prostate Cancer Metastasis Through Regulating ERK1/2-COX-2 Signaling
por: Guo, Wenjing, et al.
Publicado: (2020)

Protein kinase Ds promote tumor angiogenesis through mast cell recruitment and expression of angiogenic factors in prostate cancer microenvironment
por: Xu, Wanfu, et al.
Publicado: (2019)

Addressing the role of PKD3 in the T cell compartment with knockout mice
por: Koutník, Jiří, et al.
Publicado: (2022)

Non-Native Interactions Are Critical for Mechanical Strength in PKD Domains
por: Forman, Julia R., et al.
Publicado: (2009)

Osteoblast-Specific Deletion of Pkd2 Leads to Low-Turnover Osteopenia and Reduced Bone Marrow Adiposity
por: Xiao, Zhousheng, et al.
Publicado: (2014)

PKD1 Mono-Allelic Knockout Is Sufficient to Trigger Renal Cystogenesis in a Mini-Pig Model
por: He, Jin, et al.
Publicado: (2015)

Design, Synthesis, and Biological Evaluation of PKD Inhibitors
por: George, Kara M., et al.
Publicado: (2011)

Pkd1 and Pkd2 Are Required for Normal Placental Development
por: Garcia-Gonzalez, Miguel A., et al.
Publicado: (2010)

p53 mutation regulates PKD genes and results in co-occurrence of PKD and tumorigenesis
por: Li, Haili, et al.
Publicado: (2019)

Identified eleven exon variants in PKD1 and PKD2 genes that altered RNA splicing by minigene assay
por: Liu, Xuyan, et al.
Publicado: (2023)

Interplay of PKD3 with SREBP1 Promotes Cell Growth via Upregulating Lipogenesis in Prostate Cancer Cells
por: Li, Ling, et al.
Publicado: (2019)

β2AR-HIF-1α-CXCL12 signaling of osteoblasts activated by isoproterenol promotes migration and invasion of prostate cancer cells
por: Huang, Zhibin, et al.
Publicado: (2019)

High Resolution Melt analysis for mutation screening in PKD1 and PKD2
por: Bataille, Stanislas, et al.
Publicado: (2011)

TSC2/PKD1 contiguous deletion syndrome in a pregnant woman: A case report
por: Huang, Shaofang, et al.
Publicado: (2023)

Structural basis for Ca(2+) activation of the heteromeric PKD1L3/PKD2L1 channel
por: Su, Qiang, et al.
Publicado: (2021)

Identification of ADPKD-Related Genes and Pathways in Cells Overexpressing PKD2
por: Zhang, Zhe, et al.
Publicado: (2020)

A novel PKD2L1 C-terminal domain critical for trimerization and channel function
por: Zheng, Wang, et al.
Publicado: (2015)

BK Knockout by TALEN-Mediated Gene Targeting in Osteoblasts: KCNMA1 Determines the Proliferation and Differentiation of Osteoblasts
por: Hei, Hongya, et al.
Publicado: (2016)

PKD1 deficiency induces Bronchiectasis in a porcine ADPKD model
por: Wang, Runming, et al.
Publicado: (2022)

Role of PKD2 in the endoplasmic reticulum calcium homeostasis
por: Liu, Xiong, et al.
Publicado: (2022)

PKD1 and PKD2 mutations in Slovenian families with autosomal dominant polycystic kidney disease
por: Vouk, Katja, et al.
Publicado: (2006)

Correction to: PKD1 deficiency induces Bronchiectasis in a porcine ADPKD model
por: Wang, Runming, et al.
Publicado: (2022)

GPCR-mediated PLCβγ/PKCβ/PKD signaling pathway regulates the cofilin phosphatase slingshot 2 in neutrophil chemotaxis
por: Xu, Xuehua, et al.
Publicado: (2015)

Discovery of Diverse Small Molecule Chemotypes with Cell-Based PKD1 Inhibitory Activity
por: Sharlow, Elizabeth R., et al.
Publicado: (2011)

Polycystic Kidney Disease Caused by Bilineal Inheritance of Truncating PKD1 as Well as PKD2 Mutations
por: Losekoot, Monique, et al.
Publicado: (2020)

PKD1 and PKD2 mRNA cis-inhibition drives polycystic kidney disease progression
por: Lakhia, Ronak, et al.
Publicado: (2022)

Potential Role of HMGCS2 in Tumor Angiogenesis in Colorectal Cancer and Its Potential Use as a Diagnostic Marker
por: Zou, Kejian, et al.
Publicado: (2019)

Small Interactor of PKD2 (SIP), a novel PKD2-related single-pass transmembrane protein, is required for proteolytic processing and ciliary import of Chlamydomonas PKD2
por: Das, Poulomi, et al.
Publicado: (2023)

Role of PKD2 in Rheotaxis in Dictyostelium
por: Lima, Wanessa C., et al.
Publicado: (2014)

Identification of novel PKD1 and PKD2 mutations in Korean patients with autosomal dominant polycystic kidney disease
por: Choi, Rihwa, et al.
Publicado: (2014)

PKD1 Compared With PKD2 Genotype and Cardiac Hospitalizations in the Halt Progression of Polycystic Kidney Disease Studies
por: Steele, Cortney, et al.
Publicado: (2021)

Identification of novel PKD1 and PKD2 mutations in a Chinese population with autosomal dominant polycystic kidney disease
por: Liu, Bei, et al.
Publicado: (2015)

Prediction of Renal Prognosis in Patients with Autosomal Dominant Polycystic Kidney Disease Using PKD1/PKD2 Mutations
por: Kataoka, Hiroshi, et al.
Publicado: (2020)

Correction: Role of PKD2 in Rheotaxis in Dictyostelium
Publicado: (2014)

Diagnosis of autosomal dominant polycystic kidney disease using efficient PKD1 and PKD2 targeted next-generation sequencing
por: Trujillano, Daniel, et al.
Publicado: (2014)

The response of PKD1L3 / PKD2L1 to acid stimuli is inhibited by capsaicin and its pungent analogs
por: Ishii, Sho, et al.
Publicado: (2012)

Corrigendum: Identification of novel PKD1 and PKD2 mutations in a Chinese population with autosomal dominant polycystic kidney disease
por: Liu, Bei, et al.
Publicado: (2016)

Deciphering Variability of PKD1 and PKD2 in an Italian Cohort of 643 Patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD)
por: Carrera, Paola, et al.
Publicado: (2016)

EGCG modulates PKD1 and ferroptosis to promote recovery in ST rats
por: Wang, Jianjun, et al.
Publicado: (2020)

Lipin1 Is Involved in the Pathogenesis of Diabetic Encephalopathy through the PKD/Limk/Cofilin Signaling Pathway
por: Xie, Min, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_l3dvebtbta6i1ia4c50396npjn