Starved epithelial cells uptake extracellular matrix for survival

Extracellular matrix adhesion is required for normal epithelial cell survival, nutrient uptake and metabolism. This requirement can be overcome by oncogene activation. Interestingly, inhibition of PI3K/mTOR leads to apoptosis of matrix-detached, but not matrix-attached cancer cells, suggesting that...

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Detalles Bibliográficos
Autores principales: Muranen, Taru, Iwanicki, Marcin P., Curry, Natasha L., Hwang, Julie, DuBois, Cory D., Coloff, Jonathan L., Hitchcock, Daniel S., Clish, Clary B., Brugge, Joan S., Kalaany, Nada Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5234072/
https://www.ncbi.nlm.nih.gov/pubmed/28071763
http://dx.doi.org/10.1038/ncomms13989

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