Structural basis of human PCNA sliding on DNA

Sliding clamps encircle DNA and tether polymerases and other factors to the genomic template. However, the molecular mechanism of clamp sliding on DNA is unknown. Using crystallography, NMR and molecular dynamics simulations, here we show that the human clamp PCNA recognizes DNA through a double pat...

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Detalles Bibliográficos
Autores principales: De March, Matteo, Merino, Nekane, Barrera-Vilarmau, Susana, Crehuet, Ramon, Onesti, Silvia, Blanco, Francisco J., De Biasio, Alfredo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5234079/
https://www.ncbi.nlm.nih.gov/pubmed/28071730
http://dx.doi.org/10.1038/ncomms13935

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