Prophylactic orthosteric inhibition of leukocyte integrin CD11b/CD18 prevents long-term fibrotic kidney failure in cynomolgus monkeys

Ischaemic acute kidney injury (AKI), an inflammatory disease process, often progresses to chronic kidney disease (CKD), with no available effective prophylaxis. This is in part due to lack of clinically relevant CKD models in non-human primates. Here we demonstrate that inhibition of the archetypal...

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Detalles Bibliográficos
Autores principales: Dehnadi, Abbas, Benedict Cosimi, A., Neal Smith, Rex, Li, Xiangen, Alonso, José L., Means, Terry K., Arnaout, M. Amin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5234083/
https://www.ncbi.nlm.nih.gov/pubmed/28071653
http://dx.doi.org/10.1038/ncomms13899

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