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Genistein protects against Aβ(25–35) induced apoptosis of PC12 cells through JNK signaling and modulation of Bcl-2 family messengers

BACKGROUND: Deposition of aggregated amyloid beta (Aβ) protein is hallmark of Alzheimer’s disease, leading to dysfunction and apoptosis of neurons. The isoflavone phytoestrogen compound genistein (Gen) exerts a significant protective effect against Aβ(25–35) induced neurotoxicity and mitochondrial d...

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Detalles Bibliográficos
Autores principales:	You, Fuling, Li, Qiao, Jin, Guifang, Zheng, Yaojie, Chen, Jingrong, Yang, Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5234099/ https://www.ncbi.nlm.nih.gov/pubmed/28081713 http://dx.doi.org/10.1186/s12868-016-0329-9

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