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WWL70 attenuates PGE(2) production derived from 2-arachidonoylglycerol in microglia by ABHD6-independent mechanism

BACKGROUND: α/β-Hydrolase domain 6 (ABHD6) is one of the major enzymes for endocannabinoid 2-arachidonoylglycerol (2-AG) hydrolysis in microglia cells. Our recent studies have shown that a selective ABHD6 inhibitor WWL70 has anti-inflammatory and neuroprotective effects in animal models of traumatic...

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Detalles Bibliográficos
Autores principales:	Tanaka, Mikiei, Moran, Sean, Wen, Jie, Affram, Kwame, Chen, Tinghua, Symes, Aviva J., Zhang, Yumin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5234251/ https://www.ncbi.nlm.nih.gov/pubmed/28086912 http://dx.doi.org/10.1186/s12974-016-0783-4

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