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Early Infant Feeding Practices May Influence the Onset of Symptomatic Celiac Disease

PURPOSE: To study whether breastfeeding and breastfeeding status during gluten introduction influences the age at diagnosis of celiac disease (CD). In addition to study, whether the timing of gluten introduction influences the age at diagnosis of CD. METHODS: It was a hospital based observational st...

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Autores principales: Vajpayee, Shailja, Sharma, Shiv Dayal, Gupta, Rajkumar, Goyal, Alok, Sharma, Aakash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5234418/
https://www.ncbi.nlm.nih.gov/pubmed/28090467
http://dx.doi.org/10.5223/pghn.2016.19.4.229
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author Vajpayee, Shailja
Sharma, Shiv Dayal
Gupta, Rajkumar
Goyal, Alok
Sharma, Aakash
author_facet Vajpayee, Shailja
Sharma, Shiv Dayal
Gupta, Rajkumar
Goyal, Alok
Sharma, Aakash
author_sort Vajpayee, Shailja
collection PubMed
description PURPOSE: To study whether breastfeeding and breastfeeding status during gluten introduction influences the age at diagnosis of celiac disease (CD). In addition to study, whether the timing of gluten introduction influences the age at diagnosis of CD. METHODS: It was a hospital based observational study. Total 198 patients diagnosed with CD as per modified European Society of Pediatric Gastroenterology, Hepatology and Nutrition (2012) criteria, aged between 6 months to 6 years were included. Detail history taken with special emphasis on breastfeeding and age of gluten introduction. Standard statistical methods used to analyze the data. RESULTS: Mean±standard deviation age of onset and diagnosis of CD in breastfed cases was 2.81±1.42 years and 3.68 ±1.55 years respectively as compared to 1.84±1.36 years and 2.70±1.65 years respectively in not breastfed cases (p<0.05). Those who had continued breastfeeding during gluten introduction and of longer duration had significantly delayed onset of disease. The age at onset of CD was under one year in 40.42% of the cases, who had started gluten before 6 months of age compared to only 12.58% of those who had started gluten later (p<0.001). The proposed statistical model showed that two variables, i.e., breast feeding status during gluten introduction and age at gluten introduction positively influencing the age at diagnosis of CD. CONCLUSION: Delayed gluten introduction to infant's diet along with continuing breastfeeding, delays symptomatic CD. However, it is not clear from our study that these infant feeding practices provide permanent protection against the disease or merely delays the symptoms.
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spelling pubmed-52344182017-01-13 Early Infant Feeding Practices May Influence the Onset of Symptomatic Celiac Disease Vajpayee, Shailja Sharma, Shiv Dayal Gupta, Rajkumar Goyal, Alok Sharma, Aakash Pediatr Gastroenterol Hepatol Nutr Original Article PURPOSE: To study whether breastfeeding and breastfeeding status during gluten introduction influences the age at diagnosis of celiac disease (CD). In addition to study, whether the timing of gluten introduction influences the age at diagnosis of CD. METHODS: It was a hospital based observational study. Total 198 patients diagnosed with CD as per modified European Society of Pediatric Gastroenterology, Hepatology and Nutrition (2012) criteria, aged between 6 months to 6 years were included. Detail history taken with special emphasis on breastfeeding and age of gluten introduction. Standard statistical methods used to analyze the data. RESULTS: Mean±standard deviation age of onset and diagnosis of CD in breastfed cases was 2.81±1.42 years and 3.68 ±1.55 years respectively as compared to 1.84±1.36 years and 2.70±1.65 years respectively in not breastfed cases (p<0.05). Those who had continued breastfeeding during gluten introduction and of longer duration had significantly delayed onset of disease. The age at onset of CD was under one year in 40.42% of the cases, who had started gluten before 6 months of age compared to only 12.58% of those who had started gluten later (p<0.001). The proposed statistical model showed that two variables, i.e., breast feeding status during gluten introduction and age at gluten introduction positively influencing the age at diagnosis of CD. CONCLUSION: Delayed gluten introduction to infant's diet along with continuing breastfeeding, delays symptomatic CD. However, it is not clear from our study that these infant feeding practices provide permanent protection against the disease or merely delays the symptoms. The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition 2016-12 2016-12-28 /pmc/articles/PMC5234418/ /pubmed/28090467 http://dx.doi.org/10.5223/pghn.2016.19.4.229 Text en Copyright © 2016 by The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Vajpayee, Shailja
Sharma, Shiv Dayal
Gupta, Rajkumar
Goyal, Alok
Sharma, Aakash
Early Infant Feeding Practices May Influence the Onset of Symptomatic Celiac Disease
title Early Infant Feeding Practices May Influence the Onset of Symptomatic Celiac Disease
title_full Early Infant Feeding Practices May Influence the Onset of Symptomatic Celiac Disease
title_fullStr Early Infant Feeding Practices May Influence the Onset of Symptomatic Celiac Disease
title_full_unstemmed Early Infant Feeding Practices May Influence the Onset of Symptomatic Celiac Disease
title_short Early Infant Feeding Practices May Influence the Onset of Symptomatic Celiac Disease
title_sort early infant feeding practices may influence the onset of symptomatic celiac disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5234418/
https://www.ncbi.nlm.nih.gov/pubmed/28090467
http://dx.doi.org/10.5223/pghn.2016.19.4.229
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