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Early Infant Feeding Practices May Influence the Onset of Symptomatic Celiac Disease
PURPOSE: To study whether breastfeeding and breastfeeding status during gluten introduction influences the age at diagnosis of celiac disease (CD). In addition to study, whether the timing of gluten introduction influences the age at diagnosis of CD. METHODS: It was a hospital based observational st...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5234418/ https://www.ncbi.nlm.nih.gov/pubmed/28090467 http://dx.doi.org/10.5223/pghn.2016.19.4.229 |
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author | Vajpayee, Shailja Sharma, Shiv Dayal Gupta, Rajkumar Goyal, Alok Sharma, Aakash |
author_facet | Vajpayee, Shailja Sharma, Shiv Dayal Gupta, Rajkumar Goyal, Alok Sharma, Aakash |
author_sort | Vajpayee, Shailja |
collection | PubMed |
description | PURPOSE: To study whether breastfeeding and breastfeeding status during gluten introduction influences the age at diagnosis of celiac disease (CD). In addition to study, whether the timing of gluten introduction influences the age at diagnosis of CD. METHODS: It was a hospital based observational study. Total 198 patients diagnosed with CD as per modified European Society of Pediatric Gastroenterology, Hepatology and Nutrition (2012) criteria, aged between 6 months to 6 years were included. Detail history taken with special emphasis on breastfeeding and age of gluten introduction. Standard statistical methods used to analyze the data. RESULTS: Mean±standard deviation age of onset and diagnosis of CD in breastfed cases was 2.81±1.42 years and 3.68 ±1.55 years respectively as compared to 1.84±1.36 years and 2.70±1.65 years respectively in not breastfed cases (p<0.05). Those who had continued breastfeeding during gluten introduction and of longer duration had significantly delayed onset of disease. The age at onset of CD was under one year in 40.42% of the cases, who had started gluten before 6 months of age compared to only 12.58% of those who had started gluten later (p<0.001). The proposed statistical model showed that two variables, i.e., breast feeding status during gluten introduction and age at gluten introduction positively influencing the age at diagnosis of CD. CONCLUSION: Delayed gluten introduction to infant's diet along with continuing breastfeeding, delays symptomatic CD. However, it is not clear from our study that these infant feeding practices provide permanent protection against the disease or merely delays the symptoms. |
format | Online Article Text |
id | pubmed-5234418 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition |
record_format | MEDLINE/PubMed |
spelling | pubmed-52344182017-01-13 Early Infant Feeding Practices May Influence the Onset of Symptomatic Celiac Disease Vajpayee, Shailja Sharma, Shiv Dayal Gupta, Rajkumar Goyal, Alok Sharma, Aakash Pediatr Gastroenterol Hepatol Nutr Original Article PURPOSE: To study whether breastfeeding and breastfeeding status during gluten introduction influences the age at diagnosis of celiac disease (CD). In addition to study, whether the timing of gluten introduction influences the age at diagnosis of CD. METHODS: It was a hospital based observational study. Total 198 patients diagnosed with CD as per modified European Society of Pediatric Gastroenterology, Hepatology and Nutrition (2012) criteria, aged between 6 months to 6 years were included. Detail history taken with special emphasis on breastfeeding and age of gluten introduction. Standard statistical methods used to analyze the data. RESULTS: Mean±standard deviation age of onset and diagnosis of CD in breastfed cases was 2.81±1.42 years and 3.68 ±1.55 years respectively as compared to 1.84±1.36 years and 2.70±1.65 years respectively in not breastfed cases (p<0.05). Those who had continued breastfeeding during gluten introduction and of longer duration had significantly delayed onset of disease. The age at onset of CD was under one year in 40.42% of the cases, who had started gluten before 6 months of age compared to only 12.58% of those who had started gluten later (p<0.001). The proposed statistical model showed that two variables, i.e., breast feeding status during gluten introduction and age at gluten introduction positively influencing the age at diagnosis of CD. CONCLUSION: Delayed gluten introduction to infant's diet along with continuing breastfeeding, delays symptomatic CD. However, it is not clear from our study that these infant feeding practices provide permanent protection against the disease or merely delays the symptoms. The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition 2016-12 2016-12-28 /pmc/articles/PMC5234418/ /pubmed/28090467 http://dx.doi.org/10.5223/pghn.2016.19.4.229 Text en Copyright © 2016 by The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Vajpayee, Shailja Sharma, Shiv Dayal Gupta, Rajkumar Goyal, Alok Sharma, Aakash Early Infant Feeding Practices May Influence the Onset of Symptomatic Celiac Disease |
title | Early Infant Feeding Practices May Influence the Onset of Symptomatic Celiac Disease |
title_full | Early Infant Feeding Practices May Influence the Onset of Symptomatic Celiac Disease |
title_fullStr | Early Infant Feeding Practices May Influence the Onset of Symptomatic Celiac Disease |
title_full_unstemmed | Early Infant Feeding Practices May Influence the Onset of Symptomatic Celiac Disease |
title_short | Early Infant Feeding Practices May Influence the Onset of Symptomatic Celiac Disease |
title_sort | early infant feeding practices may influence the onset of symptomatic celiac disease |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5234418/ https://www.ncbi.nlm.nih.gov/pubmed/28090467 http://dx.doi.org/10.5223/pghn.2016.19.4.229 |
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