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Is the left uncinate fasciculus associated with verbal fluency decline in mild Alzheimer's disease?
The association between verbal fluency deficit in Alzheimer's disease (AD) and deterioration of specific white matter (WM) tracts is currently not well understood. Using diffusion tensor imaging, we investigated a possible association between the left uncinate fasciculus, which has been implica...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
De Gruyter
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5234520/ https://www.ncbi.nlm.nih.gov/pubmed/28123827 http://dx.doi.org/10.1515/tnsci-2016-0014 |
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author | Kljajevic, Vanja Dyrba, Martin Kasper, Elisabeth Teipel, Stefan |
author_facet | Kljajevic, Vanja Dyrba, Martin Kasper, Elisabeth Teipel, Stefan |
author_sort | Kljajevic, Vanja |
collection | PubMed |
description | The association between verbal fluency deficit in Alzheimer's disease (AD) and deterioration of specific white matter (WM) tracts is currently not well understood. Using diffusion tensor imaging, we investigated a possible association between the left uncinate fasciculus, which has been implicated in word retrieval, and verbal fluency deficit in AD. A comparison of five properties of WM (fractional anisotropy, mode of anisotropy, mean diffusivity, radial diffusivity, and axial diffusivity) in 28 mild AD patients and 26 age-, gender- and education-matched healthy controls revealed significant group differences in a range of WM tracts. Looking specifically at diffusion parameters’ values for the left uncinate fasciculus and verbal fluency scores in the AD group, we observed a positive trend between the letter fluency scores and mode of anisotropy values (r = 0.36, p = 0.55). Thus, our data suggest more global WM damage in mild AD, which also includes damage to the left uncinate fasciculus. However, damage to this particular tract is not robustly associated with verbal fluency decline at this stage of disease. |
format | Online Article Text |
id | pubmed-5234520 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | De Gruyter |
record_format | MEDLINE/PubMed |
spelling | pubmed-52345202017-01-25 Is the left uncinate fasciculus associated with verbal fluency decline in mild Alzheimer's disease? Kljajevic, Vanja Dyrba, Martin Kasper, Elisabeth Teipel, Stefan Transl Neurosci Research Article The association between verbal fluency deficit in Alzheimer's disease (AD) and deterioration of specific white matter (WM) tracts is currently not well understood. Using diffusion tensor imaging, we investigated a possible association between the left uncinate fasciculus, which has been implicated in word retrieval, and verbal fluency deficit in AD. A comparison of five properties of WM (fractional anisotropy, mode of anisotropy, mean diffusivity, radial diffusivity, and axial diffusivity) in 28 mild AD patients and 26 age-, gender- and education-matched healthy controls revealed significant group differences in a range of WM tracts. Looking specifically at diffusion parameters’ values for the left uncinate fasciculus and verbal fluency scores in the AD group, we observed a positive trend between the letter fluency scores and mode of anisotropy values (r = 0.36, p = 0.55). Thus, our data suggest more global WM damage in mild AD, which also includes damage to the left uncinate fasciculus. However, damage to this particular tract is not robustly associated with verbal fluency decline at this stage of disease. De Gruyter 2016-09-08 /pmc/articles/PMC5234520/ /pubmed/28123827 http://dx.doi.org/10.1515/tnsci-2016-0014 Text en © 2016 Vanja Kljajevic et al., published by De Gruyter Open http://creativecommons.org/licenses/by-nc-nd/3.0 This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. |
spellingShingle | Research Article Kljajevic, Vanja Dyrba, Martin Kasper, Elisabeth Teipel, Stefan Is the left uncinate fasciculus associated with verbal fluency decline in mild Alzheimer's disease? |
title | Is the left uncinate fasciculus associated with verbal fluency decline in mild Alzheimer's disease? |
title_full | Is the left uncinate fasciculus associated with verbal fluency decline in mild Alzheimer's disease? |
title_fullStr | Is the left uncinate fasciculus associated with verbal fluency decline in mild Alzheimer's disease? |
title_full_unstemmed | Is the left uncinate fasciculus associated with verbal fluency decline in mild Alzheimer's disease? |
title_short | Is the left uncinate fasciculus associated with verbal fluency decline in mild Alzheimer's disease? |
title_sort | is the left uncinate fasciculus associated with verbal fluency decline in mild alzheimer's disease? |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5234520/ https://www.ncbi.nlm.nih.gov/pubmed/28123827 http://dx.doi.org/10.1515/tnsci-2016-0014 |
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