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Association of peripheral differential leukocyte counts with dyslipidemia risk in Chinese patients with hypertension: insight from the China Stroke Primary Prevention Trial
The aim of the present study was to examine the association between peripheral differential leukocyte counts and dyslipidemia in a Chinese hypertensive population. A total of 10,866 patients with hypertension were enrolled for a comprehensive assessment of cardiovascular risk factors using data from...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society for Biochemistry and Molecular Biology
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5234728/ https://www.ncbi.nlm.nih.gov/pubmed/27879312 http://dx.doi.org/10.1194/jlr.P067686 |
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author | Liu, Yanhong Kong, Xiangyi Wang, Wen Fan, Fangfang Zhang, Yan Zhao, Min Wang, Yi Wang, Yupeng Wang, Yu Qin, Xianhui Tang, Genfu Wang, Binyan Xu, Xiping Hou, Fan Fan Gao, Wei Sun, Ningling Li, Jianping Venners, Scott A. Jiang, Shanqun Huo, Yong |
author_facet | Liu, Yanhong Kong, Xiangyi Wang, Wen Fan, Fangfang Zhang, Yan Zhao, Min Wang, Yi Wang, Yupeng Wang, Yu Qin, Xianhui Tang, Genfu Wang, Binyan Xu, Xiping Hou, Fan Fan Gao, Wei Sun, Ningling Li, Jianping Venners, Scott A. Jiang, Shanqun Huo, Yong |
author_sort | Liu, Yanhong |
collection | PubMed |
description | The aim of the present study was to examine the association between peripheral differential leukocyte counts and dyslipidemia in a Chinese hypertensive population. A total of 10,866 patients with hypertension were enrolled for a comprehensive assessment of cardiovascular risk factors using data from the China Stroke Primary Prevention Trial. Plasma lipid levels and total leukocyte, neutrophil, and lymphocyte counts were determined according to standard methods. Peripheral differential leukocyte counts were consistently and positively associated with serum total cholesterol (TC), LDL cholesterol (LDL-C), and TG levels (all P < 0.001 for trend), while inversely associated with HDL cholesterol levels (P < 0.05 for trend). In subsequent analyses where serum lipids were dichotomized (dyslipidemia/normolipidemia), we found that patients in the highest quartile of total leukocyte count (≥7.6 × 10(9) cells/l) had 1.64 times the risk of high TG [95% confidence interval (CI): 1.46, 1.85], 1.34 times the risk of high TC (95% CI: 1.20, 1.50), and 1.24 times the risk of high LDL-C (95% CI: 1.12, 1.39) compared with their counterparts in the lowest quartile of total leukocyte count. Similar patterns were also observed with neutrophils and lymphocytes. In summary, these findings indicate that elevated differential leukocyte counts are directly associated with serum lipid levels and increased odds of dyslipidemia. |
format | Online Article Text |
id | pubmed-5234728 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | The American Society for Biochemistry and Molecular Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-52347282017-01-25 Association of peripheral differential leukocyte counts with dyslipidemia risk in Chinese patients with hypertension: insight from the China Stroke Primary Prevention Trial Liu, Yanhong Kong, Xiangyi Wang, Wen Fan, Fangfang Zhang, Yan Zhao, Min Wang, Yi Wang, Yupeng Wang, Yu Qin, Xianhui Tang, Genfu Wang, Binyan Xu, Xiping Hou, Fan Fan Gao, Wei Sun, Ningling Li, Jianping Venners, Scott A. Jiang, Shanqun Huo, Yong J Lipid Res Patient-Oriented and Epidemiological Research The aim of the present study was to examine the association between peripheral differential leukocyte counts and dyslipidemia in a Chinese hypertensive population. A total of 10,866 patients with hypertension were enrolled for a comprehensive assessment of cardiovascular risk factors using data from the China Stroke Primary Prevention Trial. Plasma lipid levels and total leukocyte, neutrophil, and lymphocyte counts were determined according to standard methods. Peripheral differential leukocyte counts were consistently and positively associated with serum total cholesterol (TC), LDL cholesterol (LDL-C), and TG levels (all P < 0.001 for trend), while inversely associated with HDL cholesterol levels (P < 0.05 for trend). In subsequent analyses where serum lipids were dichotomized (dyslipidemia/normolipidemia), we found that patients in the highest quartile of total leukocyte count (≥7.6 × 10(9) cells/l) had 1.64 times the risk of high TG [95% confidence interval (CI): 1.46, 1.85], 1.34 times the risk of high TC (95% CI: 1.20, 1.50), and 1.24 times the risk of high LDL-C (95% CI: 1.12, 1.39) compared with their counterparts in the lowest quartile of total leukocyte count. Similar patterns were also observed with neutrophils and lymphocytes. In summary, these findings indicate that elevated differential leukocyte counts are directly associated with serum lipid levels and increased odds of dyslipidemia. The American Society for Biochemistry and Molecular Biology 2017-01 2016-12-29 /pmc/articles/PMC5234728/ /pubmed/27879312 http://dx.doi.org/10.1194/jlr.P067686 Text en Copyright © 2017 by the American Society for Biochemistry and Molecular Biology, Inc. http://creativecommons.org/licenses/by/4.0/ Author’s Choice—Final version free via Creative Commons CC-BY license. |
spellingShingle | Patient-Oriented and Epidemiological Research Liu, Yanhong Kong, Xiangyi Wang, Wen Fan, Fangfang Zhang, Yan Zhao, Min Wang, Yi Wang, Yupeng Wang, Yu Qin, Xianhui Tang, Genfu Wang, Binyan Xu, Xiping Hou, Fan Fan Gao, Wei Sun, Ningling Li, Jianping Venners, Scott A. Jiang, Shanqun Huo, Yong Association of peripheral differential leukocyte counts with dyslipidemia risk in Chinese patients with hypertension: insight from the China Stroke Primary Prevention Trial |
title | Association of peripheral differential leukocyte counts with dyslipidemia risk in Chinese patients with hypertension: insight from the China Stroke Primary Prevention Trial |
title_full | Association of peripheral differential leukocyte counts with dyslipidemia risk in Chinese patients with hypertension: insight from the China Stroke Primary Prevention Trial |
title_fullStr | Association of peripheral differential leukocyte counts with dyslipidemia risk in Chinese patients with hypertension: insight from the China Stroke Primary Prevention Trial |
title_full_unstemmed | Association of peripheral differential leukocyte counts with dyslipidemia risk in Chinese patients with hypertension: insight from the China Stroke Primary Prevention Trial |
title_short | Association of peripheral differential leukocyte counts with dyslipidemia risk in Chinese patients with hypertension: insight from the China Stroke Primary Prevention Trial |
title_sort | association of peripheral differential leukocyte counts with dyslipidemia risk in chinese patients with hypertension: insight from the china stroke primary prevention trial |
topic | Patient-Oriented and Epidemiological Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5234728/ https://www.ncbi.nlm.nih.gov/pubmed/27879312 http://dx.doi.org/10.1194/jlr.P067686 |
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