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Application of botulinum toxin to treat sialorrhea in amyotrophic lateral sclerosis patients: a literature review
Amyotrophic lateral sclerosis is a progressive and fatal neurodegenerative disease characterized by the degeneration of motor neurons, which are the central nervous system cells that control voluntary muscle movements. The excessive salivation (sialorrhea) is present in approximately 50% of amyotrop...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Instituto Israelita de Ensino e Pesquisa Albert Einstein
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5234759/ https://www.ncbi.nlm.nih.gov/pubmed/27759834 http://dx.doi.org/10.1590/S1679-45082016RB3594 |
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author | de Oliveira, Ademar Francisco Silva, Gêssyca Adryene de Menezes Almeida, Débora Milenna Xavier |
author_facet | de Oliveira, Ademar Francisco Silva, Gêssyca Adryene de Menezes Almeida, Débora Milenna Xavier |
author_sort | de Oliveira, Ademar Francisco |
collection | PubMed |
description | Amyotrophic lateral sclerosis is a progressive and fatal neurodegenerative disease characterized by the degeneration of motor neurons, which are the central nervous system cells that control voluntary muscle movements. The excessive salivation (sialorrhea) is present in approximately 50% of amyotrophic lateral sclerosis cases. Thus, some alternative therapeutic methods are sought, such as anticholinergic drugs and surgery. Recently the use of botulinum toxin applied at a midpoint of the salivary glands, often guided by ultrasound, have demonstrated positive results. The objective was to review the literature to demonstrate an alternative method to treatments of sialorrhea in patients with amyotrophic lateral sclerosis. In recent studies, the efficacy of botulinum toxin is confirmed, although new applications are required. Since the side effects are negligible, this is an alternative to treat amyotrophic lateral sclerosis, and other patients with diseases that present sialorrhea. |
format | Online Article Text |
id | pubmed-5234759 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Instituto Israelita de Ensino e Pesquisa Albert Einstein |
record_format | MEDLINE/PubMed |
spelling | pubmed-52347592017-02-03 Application of botulinum toxin to treat sialorrhea in amyotrophic lateral sclerosis patients: a literature review de Oliveira, Ademar Francisco Silva, Gêssyca Adryene de Menezes Almeida, Débora Milenna Xavier Einstein (Sao Paulo) Reviewing Basic Sciences Amyotrophic lateral sclerosis is a progressive and fatal neurodegenerative disease characterized by the degeneration of motor neurons, which are the central nervous system cells that control voluntary muscle movements. The excessive salivation (sialorrhea) is present in approximately 50% of amyotrophic lateral sclerosis cases. Thus, some alternative therapeutic methods are sought, such as anticholinergic drugs and surgery. Recently the use of botulinum toxin applied at a midpoint of the salivary glands, often guided by ultrasound, have demonstrated positive results. The objective was to review the literature to demonstrate an alternative method to treatments of sialorrhea in patients with amyotrophic lateral sclerosis. In recent studies, the efficacy of botulinum toxin is confirmed, although new applications are required. Since the side effects are negligible, this is an alternative to treat amyotrophic lateral sclerosis, and other patients with diseases that present sialorrhea. Instituto Israelita de Ensino e Pesquisa Albert Einstein 2016 /pmc/articles/PMC5234759/ /pubmed/27759834 http://dx.doi.org/10.1590/S1679-45082016RB3594 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviewing Basic Sciences de Oliveira, Ademar Francisco Silva, Gêssyca Adryene de Menezes Almeida, Débora Milenna Xavier Application of botulinum toxin to treat sialorrhea in amyotrophic lateral sclerosis patients: a literature review |
title | Application of botulinum toxin to treat sialorrhea in amyotrophic lateral sclerosis patients: a literature review |
title_full | Application of botulinum toxin to treat sialorrhea in amyotrophic lateral sclerosis patients: a literature review |
title_fullStr | Application of botulinum toxin to treat sialorrhea in amyotrophic lateral sclerosis patients: a literature review |
title_full_unstemmed | Application of botulinum toxin to treat sialorrhea in amyotrophic lateral sclerosis patients: a literature review |
title_short | Application of botulinum toxin to treat sialorrhea in amyotrophic lateral sclerosis patients: a literature review |
title_sort | application of botulinum toxin to treat sialorrhea in amyotrophic lateral sclerosis patients: a literature review |
topic | Reviewing Basic Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5234759/ https://www.ncbi.nlm.nih.gov/pubmed/27759834 http://dx.doi.org/10.1590/S1679-45082016RB3594 |
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