Cargando…

Sequential Targeting of CD52 and TNF Allows Early Minimization Therapy in Kidney Transplantation: From a Biomarker to Targeting in a Proof-Of-Concept Trial

BACKGROUND: There is high medical need for safe long-term immunosuppression monotherapy in kidney transplantation. Selective targeting of post-transplant alloantigen-(re)activated effector-T cells by anti-TNF antibodies after global T cell depletion may allow safe drug minimization, however, it is u...

Descripción completa

Detalles Bibliográficos
Autores principales:	Viklicky, Ondrej, Hruba, Petra, Tomiuk, Stefan, Schmitz, Sabrina, Gerstmayer, Bernhard, Sawitzki, Birgit, Miqueu, Patrick, Mrazova, Petra, Tycova, Irena, Svobodova, Eva, Honsova, Eva, Janssen, Uwe, Volk, Hans-Dieter, Reinke, Petra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5234822/ https://www.ncbi.nlm.nih.gov/pubmed/28085915 http://dx.doi.org/10.1371/journal.pone.0169624

Ejemplares similares

Effect of induction therapy on the expression of molecular markers associated with rejection and tolerance
por: Krepsova, Eva, et al.
Publicado: (2015)

Molecular Profiling of Acute and Chronic Rejections of Renal Allografts
por: Petra, Hřibová, et al.
Publicado: (2013)

Intrarenal Complement System Transcripts in Chronic Antibody-Mediated Rejection and Recurrent IgA Nephropathy in Kidney Transplantation
por: Cernoch, Marek, et al.
Publicado: (2018)

Relevance and targeting of memory T cells in transplantation
por: Sawitzki, Birgit, et al.
Publicado: (2011)

Early isolated V-lesion may not truly represent rejection of the kidney allograft
por: Wohlfahrtova, Mariana, et al.
Publicado: (2018)

Chronic Active Antibody-Mediated Rejection Is Associated With the Upregulation of Interstitial But Not Glomerular Transcripts
por: Trailin, Andriy, et al.
Publicado: (2021)

Molecular Fingerprints of Borderline Changes in Kidney Allografts Are Influenced by Donor Category
por: Hruba, Petra, et al.
Publicado: (2020)

Heterologous Cytomegalovirus and Allo-Reactivity by Shared T Cell Receptor Repertoire in Kidney Transplantation
por: Stranavova, Lucia, et al.
Publicado: (2019)

Sepsis affects kidney graft function and one-year mortality of the recipients in contrast with systemic inflammatory response
por: Protus, Marek, et al.
Publicado: (2022)

Intimal Arteritis and Microvascular Inflammation Are Associated With Inferior Kidney Graft Outcome, Regardless of Donor-Specific Antibodies
por: Novotny, Marek, et al.
Publicado: (2021)

Local Angiotensin-Converting Enzyme 2 Gene Expression in Kidney Allografts Is Not Affected by Renin-Angiotensin-Aldosterone Inhibitors
por: Cahova, Monika, et al.
Publicado: (2021)

A novel prognostic nomogram predicts premature failure of kidney allografts with IgA nephropathy recurrence
por: Bednarova, Kamila, et al.
Publicado: (2023)

Molecular Networks Involved in the Immune Control of BK Polyomavirus
por: Girmanova, Eva, et al.
Publicado: (2012)

MCPggaac haplotype is associated with poor graft survival in kidney transplant recipients with de novo thrombotic microangiopathy
por: Petr, Vojtech, et al.
Publicado: (2022)

SLCO1B1 Polymorphism is not associated with Risk of Statin-Induced Myalgia/Myopathy in a Czech Population
por: Hubáček, Jaroslav A., et al.
Publicado: (2015)

Rejection-associated Phenotype of De Novo Thrombotic Microangiopathy Represents a Risk for Premature Graft Loss
por: Petr, Vojtech, et al.
Publicado: (2021)

Ex vivo gene transfer of viral interleukin-10 to BB rat islets: no protection after transplantation to diabetic BB rats
por: Kuttler, Beate, et al.
Publicado: (2007)

Novel transcriptomic signatures associated with premature kidney allograft failure
por: Hruba, Petra, et al.
Publicado: (2023)

Outcome of 313 Czech Patients With IgA Nephropathy After Renal Transplantation
por: Maixnerova, Dita, et al.
Publicado: (2021)

To be, or not to be immunocompetent
por: Volk, Hans-Dieter, et al.
Publicado: (2013)

Predictive Potential of Flow Cytometry Crossmatching in Deceased Donor Kidney Transplant Recipients Subjected to Peritransplant Desensitization
por: Osickova, Klara, et al.
Publicado: (2021)

The impact of frailty syndrome on humoral response to SARS-CoV-2 mRNA vaccines in older kidney transplant recipients
por: Schmalz, Michal, et al.
Publicado: (2023)

Author Correction: Molecular patterns of isolated tubulitis differ from tubulitis with interstitial inflammation in early indication biopsies of kidney allografts
por: Hruba, Petra, et al.
Publicado: (2021)

Molecular patterns of isolated tubulitis differ from tubulitis with interstitial inflammation in early indication biopsies of kidney allografts
por: Hruba, Petra, et al.
Publicado: (2020)

On the clinical relevance of using complete high-resolution HLA typing for an accurate interpretation of posttransplant immune-mediated graft outcomes
por: Meneghini, Maria, et al.
Publicado: (2022)

Targeting CD20+ B-lymphocytes in inflammatory dilated cardiomyopathy with rituximab improves clinical course: a case series
por: Tschöpe, Carsten, et al.
Publicado: (2019)

Physical activity and 4-year changes in body weight in 52,498 non-obese people: the Lifelines cohort
por: Byambasukh, Oyuntugs, et al.
Publicado: (2021)

Tacrolimus CYP3A Single-Nucleotide Polymorphisms and Preformed T- and B-Cell Alloimmune Memory Improve Current Pretransplant Rejection-Risk Stratification in Kidney Transplantation
por: Crespo, Elena, et al.
Publicado: (2022)

Mechanisms of Immune Tolerance in Liver Transplantation-Crosstalk Between Alloreactive T Cells and Liver Cells With Therapeutic Prospects
por: Lei, Hong, et al.
Publicado: (2019)

Non-thermal plasma causes Pseudomonas aeruginosa biofilm release to planktonic form and inhibits production of Las-B elastase, protease and pyocyanin
por: Kašparová, Petra, et al.
Publicado: (2022)

Regulatory T cell-mediated anti-inflammatory effects promote successful tissue repair in both indirect and direct manners
por: Lei, Hong, et al.
Publicado: (2015)

When RAD52 Allows Mitosis to Accept Unscheduled DNA Synthesis
por: Franchet, Camille, et al.
Publicado: (2019)

Targeted De-Methylation of the FOXP3-TSDR Is Sufficient to Induce Physiological FOXP3 Expression but Not a Functional Treg Phenotype
por: Kressler, Christopher, et al.
Publicado: (2021)

Less renal allograft fibrosis with valganciclovir prophylaxis for cytomegalovirus compared to high-dose valacyclovir: a parallel group, open-label, randomized controlled trial
por: Reischig, Tomas, et al.
Publicado: (2018)

Comparison of the sensitivity of Danio rerio and Poecilia reticulata to silver nitrate in short-term tests
por: Doleželová, Petra, et al.
Publicado: (2008)

MSC Therapies for COVID-19: Importance of Patient Coagulopathy, Thromboprophylaxis, Cell Product Quality and Mode of Delivery for Treatment Safety and Efficacy
por: Moll, Guido, et al.
Publicado: (2020)

Transfer Learning Allows Accurate RBP Target Site Prediction with Limited Sample Sizes
por: Vaculík, Ondřej, et al.
Publicado: (2023)

The Value of a Rapid Test of Human Regulatory T Cell Function Needs to be Revised
por: Wendering, Desiree J., et al.
Publicado: (2019)

Proof-of-Concept: Antisense Oligonucleotide Mediated Skipping of Fibrillin-1 Exon 52
por: Cale, Jessica M., et al.
Publicado: (2021)

Unstable Expression of Commonly Used Reference Genes in Rat Pancreatic Islets Early after Isolation Affects Results of Gene Expression Studies
por: Kosinová, Lucie, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_4167r0kc9lcd2okarf0s4rq812