Cyclobenzaprine Raises ROS Levels in Leishmania infantum and Reduces Parasite Burden in Infected Mice

BACKGROUND: The leishmanicidal action of tricyclic antidepressants has been studied and evidences have pointed that their action is linked to inhibition of trypanothione reductase, a key enzyme in the redox metabolism of pathogenic trypanosomes. Cyclobenzaprine (CBP) is a tricyclic structurally rela...

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Detalles Bibliográficos
Autores principales: Cunha-Júnior, Edézio Ferreira, Andrade-Neto, Valter Viana, Lima, Marta Lopes, da Costa-Silva, Thais Alves, Galisteo Junior, Andres J., Abengózar, Maria A., Barbas, Coral, Rivas, Luis, Almeida-Amaral, Elmo Eduardo, Tempone, Andre Gustavo, Torres-Santos, Eduardo Caio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5234845/
https://www.ncbi.nlm.nih.gov/pubmed/28045892
http://dx.doi.org/10.1371/journal.pntd.0005281

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