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Large Animal Models: The Key to Translational Discovery in Digestive Disease Research
Gastrointestinal disease is a prevalent cause of morbidity and mortality and the use of animal models have been instrumental in studying mechanisms of digestive pathophysiology. As investigators attempt to translate the wealth of basic science information developed from rodent models, large animal m...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5235339/ https://www.ncbi.nlm.nih.gov/pubmed/28090566 http://dx.doi.org/10.1016/j.jcmgh.2016.09.003 |
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author | Ziegler, Amanda Gonzalez, Liara Blikslager, Anthony |
author_facet | Ziegler, Amanda Gonzalez, Liara Blikslager, Anthony |
author_sort | Ziegler, Amanda |
collection | PubMed |
description | Gastrointestinal disease is a prevalent cause of morbidity and mortality and the use of animal models have been instrumental in studying mechanisms of digestive pathophysiology. As investigators attempt to translate the wealth of basic science information developed from rodent models, large animal models provide a number of translational advantages. The pig, in particular, is arguably one of the most powerful models of human organ systems, including the gastrointestinal tract. The pig has provided important tools and insight into intestinal ischemia/reperfusion injury, intestinal mucosal repair, as well as new insights into esophageal injury and repair. Porcine model development has taken advantage of the size of the animal, allowing increased surgical and endoscopic access. In addition, cellular tools such as the intestinal porcine epithelial cell (IPEC-J2) line and porcine enteroids are providing the methodology to translate basic science findings using in-depth mechanistic analyses. Further opportunities in porcine digestive disease modeling include developing additional transgenic pig strains. Collectively, porcine models hold great promise for the future of clinically relevant digestive disease research. |
format | Online Article Text |
id | pubmed-5235339 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-52353392017-01-13 Large Animal Models: The Key to Translational Discovery in Digestive Disease Research Ziegler, Amanda Gonzalez, Liara Blikslager, Anthony Cell Mol Gastroenterol Hepatol Review Gastrointestinal disease is a prevalent cause of morbidity and mortality and the use of animal models have been instrumental in studying mechanisms of digestive pathophysiology. As investigators attempt to translate the wealth of basic science information developed from rodent models, large animal models provide a number of translational advantages. The pig, in particular, is arguably one of the most powerful models of human organ systems, including the gastrointestinal tract. The pig has provided important tools and insight into intestinal ischemia/reperfusion injury, intestinal mucosal repair, as well as new insights into esophageal injury and repair. Porcine model development has taken advantage of the size of the animal, allowing increased surgical and endoscopic access. In addition, cellular tools such as the intestinal porcine epithelial cell (IPEC-J2) line and porcine enteroids are providing the methodology to translate basic science findings using in-depth mechanistic analyses. Further opportunities in porcine digestive disease modeling include developing additional transgenic pig strains. Collectively, porcine models hold great promise for the future of clinically relevant digestive disease research. Elsevier 2016-09-17 /pmc/articles/PMC5235339/ /pubmed/28090566 http://dx.doi.org/10.1016/j.jcmgh.2016.09.003 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Ziegler, Amanda Gonzalez, Liara Blikslager, Anthony Large Animal Models: The Key to Translational Discovery in Digestive Disease Research |
title | Large Animal Models: The Key to Translational Discovery in Digestive Disease Research |
title_full | Large Animal Models: The Key to Translational Discovery in Digestive Disease Research |
title_fullStr | Large Animal Models: The Key to Translational Discovery in Digestive Disease Research |
title_full_unstemmed | Large Animal Models: The Key to Translational Discovery in Digestive Disease Research |
title_short | Large Animal Models: The Key to Translational Discovery in Digestive Disease Research |
title_sort | large animal models: the key to translational discovery in digestive disease research |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5235339/ https://www.ncbi.nlm.nih.gov/pubmed/28090566 http://dx.doi.org/10.1016/j.jcmgh.2016.09.003 |
work_keys_str_mv | AT ziegleramanda largeanimalmodelsthekeytotranslationaldiscoveryindigestivediseaseresearch AT gonzalezliara largeanimalmodelsthekeytotranslationaldiscoveryindigestivediseaseresearch AT blikslageranthony largeanimalmodelsthekeytotranslationaldiscoveryindigestivediseaseresearch |