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Large Animal Models: The Key to Translational Discovery in Digestive Disease Research

Gastrointestinal disease is a prevalent cause of morbidity and mortality and the use of animal models have been instrumental in studying mechanisms of digestive pathophysiology. As investigators attempt to translate the wealth of basic science information developed from rodent models, large animal m...

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Detalles Bibliográficos
Autores principales: Ziegler, Amanda, Gonzalez, Liara, Blikslager, Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5235339/
https://www.ncbi.nlm.nih.gov/pubmed/28090566
http://dx.doi.org/10.1016/j.jcmgh.2016.09.003
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author Ziegler, Amanda
Gonzalez, Liara
Blikslager, Anthony
author_facet Ziegler, Amanda
Gonzalez, Liara
Blikslager, Anthony
author_sort Ziegler, Amanda
collection PubMed
description Gastrointestinal disease is a prevalent cause of morbidity and mortality and the use of animal models have been instrumental in studying mechanisms of digestive pathophysiology. As investigators attempt to translate the wealth of basic science information developed from rodent models, large animal models provide a number of translational advantages. The pig, in particular, is arguably one of the most powerful models of human organ systems, including the gastrointestinal tract. The pig has provided important tools and insight into intestinal ischemia/reperfusion injury, intestinal mucosal repair, as well as new insights into esophageal injury and repair. Porcine model development has taken advantage of the size of the animal, allowing increased surgical and endoscopic access. In addition, cellular tools such as the intestinal porcine epithelial cell (IPEC-J2) line and porcine enteroids are providing the methodology to translate basic science findings using in-depth mechanistic analyses. Further opportunities in porcine digestive disease modeling include developing additional transgenic pig strains. Collectively, porcine models hold great promise for the future of clinically relevant digestive disease research.
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spelling pubmed-52353392017-01-13 Large Animal Models: The Key to Translational Discovery in Digestive Disease Research Ziegler, Amanda Gonzalez, Liara Blikslager, Anthony Cell Mol Gastroenterol Hepatol Review Gastrointestinal disease is a prevalent cause of morbidity and mortality and the use of animal models have been instrumental in studying mechanisms of digestive pathophysiology. As investigators attempt to translate the wealth of basic science information developed from rodent models, large animal models provide a number of translational advantages. The pig, in particular, is arguably one of the most powerful models of human organ systems, including the gastrointestinal tract. The pig has provided important tools and insight into intestinal ischemia/reperfusion injury, intestinal mucosal repair, as well as new insights into esophageal injury and repair. Porcine model development has taken advantage of the size of the animal, allowing increased surgical and endoscopic access. In addition, cellular tools such as the intestinal porcine epithelial cell (IPEC-J2) line and porcine enteroids are providing the methodology to translate basic science findings using in-depth mechanistic analyses. Further opportunities in porcine digestive disease modeling include developing additional transgenic pig strains. Collectively, porcine models hold great promise for the future of clinically relevant digestive disease research. Elsevier 2016-09-17 /pmc/articles/PMC5235339/ /pubmed/28090566 http://dx.doi.org/10.1016/j.jcmgh.2016.09.003 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Ziegler, Amanda
Gonzalez, Liara
Blikslager, Anthony
Large Animal Models: The Key to Translational Discovery in Digestive Disease Research
title Large Animal Models: The Key to Translational Discovery in Digestive Disease Research
title_full Large Animal Models: The Key to Translational Discovery in Digestive Disease Research
title_fullStr Large Animal Models: The Key to Translational Discovery in Digestive Disease Research
title_full_unstemmed Large Animal Models: The Key to Translational Discovery in Digestive Disease Research
title_short Large Animal Models: The Key to Translational Discovery in Digestive Disease Research
title_sort large animal models: the key to translational discovery in digestive disease research
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5235339/
https://www.ncbi.nlm.nih.gov/pubmed/28090566
http://dx.doi.org/10.1016/j.jcmgh.2016.09.003
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