Mitogen-activated Protein Kinase Kinase Activity Maintains Acinar-to-Ductal Metaplasia and Is Required for Organ Regeneration in Pancreatitis

BACKGROUND & AIMS: Mitogen-activated protein kinase (MAPK) signaling in the exocrine pancreas has been extensively studied in the context of pancreatic cancer, where its potential as a therapeutic target is limited by acquired drug resistance. However, its role in pancreatitis is less understood...

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Detalles Bibliográficos
Autores principales: Halbrook, Christopher J., Wen, Hui-Ju, Ruggeri, Jeanine M., Takeuchi, Kenneth K., Zhang, Yaqing, Pasca di Magliano, Marina, Crawford, Howard C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5235341/
https://www.ncbi.nlm.nih.gov/pubmed/28090569
http://dx.doi.org/10.1016/j.jcmgh.2016.09.009

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