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Modeling Dynamics and Function of Bone Marrow Cells in Mouse Liver Regeneration
In rodents and humans, the liver can efficiently restore its mass after hepatectomy. This is largely attributed to the proliferation and cell cycle re-entry of hepatocytes. On the other hand, bone marrow cells (BMCs) migrate into the liver after resection. Here, we find that a block of BMC recruitme...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5236012/ https://www.ncbi.nlm.nih.gov/pubmed/28052241 http://dx.doi.org/10.1016/j.celrep.2016.12.008 |
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author | Pedone, Elisa Olteanu, Vlad-Aris Marucci, Lucia Muñoz-Martin, Maria Isabel Youssef, Sameh A. de Bruin, Alain Cosma, Maria Pia |
author_facet | Pedone, Elisa Olteanu, Vlad-Aris Marucci, Lucia Muñoz-Martin, Maria Isabel Youssef, Sameh A. de Bruin, Alain Cosma, Maria Pia |
author_sort | Pedone, Elisa |
collection | PubMed |
description | In rodents and humans, the liver can efficiently restore its mass after hepatectomy. This is largely attributed to the proliferation and cell cycle re-entry of hepatocytes. On the other hand, bone marrow cells (BMCs) migrate into the liver after resection. Here, we find that a block of BMC recruitment into the liver severely impairs its regeneration after the surgery. Mobilized hematopoietic stem and progenitor cells (HSPCs) in the resected liver can fuse with hepatocytes, and the hybrids proliferate earlier than the hepatocytes. Genetic ablation of the hybrids severely impairs hepatocyte proliferation and liver mass regeneration. Mathematical modeling reveals a key role of bone marrow (BM)-derived hybrids to drive proliferation in the regeneration process, and predicts regeneration efficiency in experimentally non-testable conditions. In conclusion, BM-derived hybrids are essential to trigger efficient liver regeneration after hepatectomy. |
format | Online Article Text |
id | pubmed-5236012 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Cell Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-52360122017-01-24 Modeling Dynamics and Function of Bone Marrow Cells in Mouse Liver Regeneration Pedone, Elisa Olteanu, Vlad-Aris Marucci, Lucia Muñoz-Martin, Maria Isabel Youssef, Sameh A. de Bruin, Alain Cosma, Maria Pia Cell Rep Article In rodents and humans, the liver can efficiently restore its mass after hepatectomy. This is largely attributed to the proliferation and cell cycle re-entry of hepatocytes. On the other hand, bone marrow cells (BMCs) migrate into the liver after resection. Here, we find that a block of BMC recruitment into the liver severely impairs its regeneration after the surgery. Mobilized hematopoietic stem and progenitor cells (HSPCs) in the resected liver can fuse with hepatocytes, and the hybrids proliferate earlier than the hepatocytes. Genetic ablation of the hybrids severely impairs hepatocyte proliferation and liver mass regeneration. Mathematical modeling reveals a key role of bone marrow (BM)-derived hybrids to drive proliferation in the regeneration process, and predicts regeneration efficiency in experimentally non-testable conditions. In conclusion, BM-derived hybrids are essential to trigger efficient liver regeneration after hepatectomy. Cell Press 2017-01-03 /pmc/articles/PMC5236012/ /pubmed/28052241 http://dx.doi.org/10.1016/j.celrep.2016.12.008 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Pedone, Elisa Olteanu, Vlad-Aris Marucci, Lucia Muñoz-Martin, Maria Isabel Youssef, Sameh A. de Bruin, Alain Cosma, Maria Pia Modeling Dynamics and Function of Bone Marrow Cells in Mouse Liver Regeneration |
title | Modeling Dynamics and Function of Bone Marrow Cells in Mouse Liver Regeneration |
title_full | Modeling Dynamics and Function of Bone Marrow Cells in Mouse Liver Regeneration |
title_fullStr | Modeling Dynamics and Function of Bone Marrow Cells in Mouse Liver Regeneration |
title_full_unstemmed | Modeling Dynamics and Function of Bone Marrow Cells in Mouse Liver Regeneration |
title_short | Modeling Dynamics and Function of Bone Marrow Cells in Mouse Liver Regeneration |
title_sort | modeling dynamics and function of bone marrow cells in mouse liver regeneration |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5236012/ https://www.ncbi.nlm.nih.gov/pubmed/28052241 http://dx.doi.org/10.1016/j.celrep.2016.12.008 |
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