Soluble Toll-like receptor 2 is a biomarker for sepsis in critically ill patients with multi-organ failure within 12 h of ICU admission

Soluble TLR2 levels are elevated in infective and inflammatory conditions, but its diagnostic value with sepsis-induced multi-organ failure has not been evaluated. 37 patients with a diagnosis of severe sepsis/septic shock (sepsis) and 27 patients with organ failure without infection (SIRS) were stu...

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Autores principales: Holst, Benjamin, Szakmany, Tamas, Raby, Anne-Catherine, Hamlyn, Vincent, Durno, Kimberley, Hall, Judith E., Labéta, Mario O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2017
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5236041/
https://www.ncbi.nlm.nih.gov/pubmed/28092080
http://dx.doi.org/10.1186/s40635-016-0116-z
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author Holst, Benjamin
Szakmany, Tamas
Raby, Anne-Catherine
Hamlyn, Vincent
Durno, Kimberley
Hall, Judith E.
Labéta, Mario O.
author_facet Holst, Benjamin
Szakmany, Tamas
Raby, Anne-Catherine
Hamlyn, Vincent
Durno, Kimberley
Hall, Judith E.
Labéta, Mario O.
author_sort Holst, Benjamin
collection PubMed
description Soluble TLR2 levels are elevated in infective and inflammatory conditions, but its diagnostic value with sepsis-induced multi-organ failure has not been evaluated. 37 patients with a diagnosis of severe sepsis/septic shock (sepsis) and 27 patients with organ failure without infection (SIRS) were studied. Median (IQR) plasma sTLR2 levels were 2.7 ng/ml (1.4–6.1) in sepsis and 0.6 ng/ml (0.4–0.9) in SIRS p < 0.001. sTLR2 showed good diagnostic value for sepsis at cut-off of 1.0 ng/ml, AUC:0.959. We report the ability of sTLR2 levels to discriminate between sepsis and SIRS within 12 h of ICU admission in patients with multi-organ failure.
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spelling pubmed-52360412017-01-25 Soluble Toll-like receptor 2 is a biomarker for sepsis in critically ill patients with multi-organ failure within 12 h of ICU admission Holst, Benjamin Szakmany, Tamas Raby, Anne-Catherine Hamlyn, Vincent Durno, Kimberley Hall, Judith E. Labéta, Mario O. Intensive Care Med Exp Letter to the Editor Soluble TLR2 levels are elevated in infective and inflammatory conditions, but its diagnostic value with sepsis-induced multi-organ failure has not been evaluated. 37 patients with a diagnosis of severe sepsis/septic shock (sepsis) and 27 patients with organ failure without infection (SIRS) were studied. Median (IQR) plasma sTLR2 levels were 2.7 ng/ml (1.4–6.1) in sepsis and 0.6 ng/ml (0.4–0.9) in SIRS p < 0.001. sTLR2 showed good diagnostic value for sepsis at cut-off of 1.0 ng/ml, AUC:0.959. We report the ability of sTLR2 levels to discriminate between sepsis and SIRS within 12 h of ICU admission in patients with multi-organ failure. Springer International Publishing 2017-01-13 /pmc/articles/PMC5236041/ /pubmed/28092080 http://dx.doi.org/10.1186/s40635-016-0116-z Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Letter to the Editor
Holst, Benjamin
Szakmany, Tamas
Raby, Anne-Catherine
Hamlyn, Vincent
Durno, Kimberley
Hall, Judith E.
Labéta, Mario O.
Soluble Toll-like receptor 2 is a biomarker for sepsis in critically ill patients with multi-organ failure within 12 h of ICU admission
title Soluble Toll-like receptor 2 is a biomarker for sepsis in critically ill patients with multi-organ failure within 12 h of ICU admission
title_full Soluble Toll-like receptor 2 is a biomarker for sepsis in critically ill patients with multi-organ failure within 12 h of ICU admission
title_fullStr Soluble Toll-like receptor 2 is a biomarker for sepsis in critically ill patients with multi-organ failure within 12 h of ICU admission
title_full_unstemmed Soluble Toll-like receptor 2 is a biomarker for sepsis in critically ill patients with multi-organ failure within 12 h of ICU admission
title_short Soluble Toll-like receptor 2 is a biomarker for sepsis in critically ill patients with multi-organ failure within 12 h of ICU admission
title_sort soluble toll-like receptor 2 is a biomarker for sepsis in critically ill patients with multi-organ failure within 12 h of icu admission
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5236041/
https://www.ncbi.nlm.nih.gov/pubmed/28092080
http://dx.doi.org/10.1186/s40635-016-0116-z
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