Cargando…
Transfer factor for carbon monoxide in patients with COPD and diabetes: results from the German COSYCONET cohort
BACKGROUND: An impairment of CO diffusing capacity has been shown in diabetic patients without lung disease. We analyzed how diffusing capacity in patients with COPD is affected by the concurrent diagnosis of diabetes. METHODS: Data from the initial visit of the German COPD cohort COSYCONET were use...
Autores principales: | , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237203/ https://www.ncbi.nlm.nih.gov/pubmed/28086884 http://dx.doi.org/10.1186/s12931-016-0499-0 |
_version_ | 1782495486364614656 |
---|---|
author | Kahnert, Kathrin Lucke, Tanja Biertz, Frank Lechner, Andreas Watz, Henrik Alter, Peter Bals, Robert Behr, Jürgen Holle, Rolf Huber, Rudolf M. Karrasch, Stefan Stubbe, Beate Wacker, Margarethe Söhler, Sandra Wouters, Emiel F. M. Vogelmeier, Claus Jörres, Rudolf A. |
author_facet | Kahnert, Kathrin Lucke, Tanja Biertz, Frank Lechner, Andreas Watz, Henrik Alter, Peter Bals, Robert Behr, Jürgen Holle, Rolf Huber, Rudolf M. Karrasch, Stefan Stubbe, Beate Wacker, Margarethe Söhler, Sandra Wouters, Emiel F. M. Vogelmeier, Claus Jörres, Rudolf A. |
author_sort | Kahnert, Kathrin |
collection | PubMed |
description | BACKGROUND: An impairment of CO diffusing capacity has been shown in diabetic patients without lung disease. We analyzed how diffusing capacity in patients with COPD is affected by the concurrent diagnosis of diabetes. METHODS: Data from the initial visit of the German COPD cohort COSYCONET were used for analysis. 2575 patients with complete lung function data were included, among them 358 defined as diabetics with a reported physician diagnosis of diabetes and/or specific medication. Pairwise comparisons between groups and multivariate regression models were used to identify variables predicting the CO transfer factor (TLCO%pred) and the transfer coefficient (KCO%pred). RESULTS: COPD patients with diabetes differed from those without diabetes regarding lung function, anthropometric, clinical and laboratory parameters. Moreover, gender was an important covariate. After correction for lung function, gender and body mass index (BMI), TLCO%pred did not significantly differ between patients with and without diabetes. The results for the transfer coefficient KCO were similar, demonstrating an important role of the confounding factors RV%pred, TLC%pred, ITGV%pred, FEV(1)%pred, FEV(1)/FVC, age, packyears, creatinine and BMI. There was not even a tendency towards lower values in diabetes. CONCLUSION: The analysis of data from a COPD cohort showed no significant differences of CO transport parameters between COPD patients with and without diabetes, if BMI, gender and the reduction in lung volumes were taken into account. This result is in contrast to observations in lung-healthy subjects with diabetes and raises the question which factors, among them potential anti-inflammatory effects of anti-diabetes medication are responsible for this finding. |
format | Online Article Text |
id | pubmed-5237203 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-52372032017-01-18 Transfer factor for carbon monoxide in patients with COPD and diabetes: results from the German COSYCONET cohort Kahnert, Kathrin Lucke, Tanja Biertz, Frank Lechner, Andreas Watz, Henrik Alter, Peter Bals, Robert Behr, Jürgen Holle, Rolf Huber, Rudolf M. Karrasch, Stefan Stubbe, Beate Wacker, Margarethe Söhler, Sandra Wouters, Emiel F. M. Vogelmeier, Claus Jörres, Rudolf A. Respir Res Research BACKGROUND: An impairment of CO diffusing capacity has been shown in diabetic patients without lung disease. We analyzed how diffusing capacity in patients with COPD is affected by the concurrent diagnosis of diabetes. METHODS: Data from the initial visit of the German COPD cohort COSYCONET were used for analysis. 2575 patients with complete lung function data were included, among them 358 defined as diabetics with a reported physician diagnosis of diabetes and/or specific medication. Pairwise comparisons between groups and multivariate regression models were used to identify variables predicting the CO transfer factor (TLCO%pred) and the transfer coefficient (KCO%pred). RESULTS: COPD patients with diabetes differed from those without diabetes regarding lung function, anthropometric, clinical and laboratory parameters. Moreover, gender was an important covariate. After correction for lung function, gender and body mass index (BMI), TLCO%pred did not significantly differ between patients with and without diabetes. The results for the transfer coefficient KCO were similar, demonstrating an important role of the confounding factors RV%pred, TLC%pred, ITGV%pred, FEV(1)%pred, FEV(1)/FVC, age, packyears, creatinine and BMI. There was not even a tendency towards lower values in diabetes. CONCLUSION: The analysis of data from a COPD cohort showed no significant differences of CO transport parameters between COPD patients with and without diabetes, if BMI, gender and the reduction in lung volumes were taken into account. This result is in contrast to observations in lung-healthy subjects with diabetes and raises the question which factors, among them potential anti-inflammatory effects of anti-diabetes medication are responsible for this finding. BioMed Central 2017-01-13 2017 /pmc/articles/PMC5237203/ /pubmed/28086884 http://dx.doi.org/10.1186/s12931-016-0499-0 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Kahnert, Kathrin Lucke, Tanja Biertz, Frank Lechner, Andreas Watz, Henrik Alter, Peter Bals, Robert Behr, Jürgen Holle, Rolf Huber, Rudolf M. Karrasch, Stefan Stubbe, Beate Wacker, Margarethe Söhler, Sandra Wouters, Emiel F. M. Vogelmeier, Claus Jörres, Rudolf A. Transfer factor for carbon monoxide in patients with COPD and diabetes: results from the German COSYCONET cohort |
title | Transfer factor for carbon monoxide in patients with COPD and diabetes: results from the German COSYCONET cohort |
title_full | Transfer factor for carbon monoxide in patients with COPD and diabetes: results from the German COSYCONET cohort |
title_fullStr | Transfer factor for carbon monoxide in patients with COPD and diabetes: results from the German COSYCONET cohort |
title_full_unstemmed | Transfer factor for carbon monoxide in patients with COPD and diabetes: results from the German COSYCONET cohort |
title_short | Transfer factor for carbon monoxide in patients with COPD and diabetes: results from the German COSYCONET cohort |
title_sort | transfer factor for carbon monoxide in patients with copd and diabetes: results from the german cosyconet cohort |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237203/ https://www.ncbi.nlm.nih.gov/pubmed/28086884 http://dx.doi.org/10.1186/s12931-016-0499-0 |
work_keys_str_mv | AT kahnertkathrin transferfactorforcarbonmonoxideinpatientswithcopdanddiabetesresultsfromthegermancosyconetcohort AT lucketanja transferfactorforcarbonmonoxideinpatientswithcopdanddiabetesresultsfromthegermancosyconetcohort AT biertzfrank transferfactorforcarbonmonoxideinpatientswithcopdanddiabetesresultsfromthegermancosyconetcohort AT lechnerandreas transferfactorforcarbonmonoxideinpatientswithcopdanddiabetesresultsfromthegermancosyconetcohort AT watzhenrik transferfactorforcarbonmonoxideinpatientswithcopdanddiabetesresultsfromthegermancosyconetcohort AT alterpeter transferfactorforcarbonmonoxideinpatientswithcopdanddiabetesresultsfromthegermancosyconetcohort AT balsrobert transferfactorforcarbonmonoxideinpatientswithcopdanddiabetesresultsfromthegermancosyconetcohort AT behrjurgen transferfactorforcarbonmonoxideinpatientswithcopdanddiabetesresultsfromthegermancosyconetcohort AT hollerolf transferfactorforcarbonmonoxideinpatientswithcopdanddiabetesresultsfromthegermancosyconetcohort AT huberrudolfm transferfactorforcarbonmonoxideinpatientswithcopdanddiabetesresultsfromthegermancosyconetcohort AT karraschstefan transferfactorforcarbonmonoxideinpatientswithcopdanddiabetesresultsfromthegermancosyconetcohort AT stubbebeate transferfactorforcarbonmonoxideinpatientswithcopdanddiabetesresultsfromthegermancosyconetcohort AT wackermargarethe transferfactorforcarbonmonoxideinpatientswithcopdanddiabetesresultsfromthegermancosyconetcohort AT sohlersandra transferfactorforcarbonmonoxideinpatientswithcopdanddiabetesresultsfromthegermancosyconetcohort AT woutersemielfm transferfactorforcarbonmonoxideinpatientswithcopdanddiabetesresultsfromthegermancosyconetcohort AT vogelmeierclaus transferfactorforcarbonmonoxideinpatientswithcopdanddiabetesresultsfromthegermancosyconetcohort AT jorresrudolfa transferfactorforcarbonmonoxideinpatientswithcopdanddiabetesresultsfromthegermancosyconetcohort AT transferfactorforcarbonmonoxideinpatientswithcopdanddiabetesresultsfromthegermancosyconetcohort |