Alpha-enolase (ENO1) controls alpha v/beta 3 integrin expression and regulates pancreatic cancer adhesion, invasion, and metastasis

BACKGROUND: We have previously shown that in pancreatic ductal adenocarcinoma (PDA) cells, the glycolytic enzyme alpha-enolase (ENO1) also acts as a plasminogen receptor and promotes invasion and metastasis formation. Moreover, ENO1 silencing in PDA cells induces oxidative stress, senescence and pro...

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Detalles Bibliográficos
Autores principales: Principe, Moitza, Borgoni, Simone, Cascione, Mariafrancesca, Chattaragada, Michelle Samuel, Ferri-Borgogno, Sammy, Capello, Michela, Bulfamante, Sara, Chapelle, Jennifer, Di Modugno, Francesca, Defilippi, Paola, Nisticò, Paola, Cappello, Paola, Riganti, Chiara, Leporatti, Stefano, Novelli, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237223/
https://www.ncbi.nlm.nih.gov/pubmed/28086938
http://dx.doi.org/10.1186/s13045-016-0385-8

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