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Relationship between the uptake of (18)F-borono-L-phenylalanine and L-[methyl-(11)C] methionine in head and neck tumors and normal organs

BACKGROUND AND PURPOSE: The purpose of this study was to determine the distribution of 4-borono-2-(18)F-fluoro-phenylalanine ((18)F-BPA) and L-[methyl-(11)C] methionine ((11)C-Met) in normal organs and tumors and to evaluate the usefulness of (11)C-Met/PET in screening potential candidates for boron...

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Autores principales: Watanabe, Yoshiaki, Kurihara, Hiroaki, Itami, Jun, Sasaki, Ryohei, Arai, Yasuaki, Sugimura, Kazuro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237505/
https://www.ncbi.nlm.nih.gov/pubmed/28088230
http://dx.doi.org/10.1186/s13014-017-0763-6
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author Watanabe, Yoshiaki
Kurihara, Hiroaki
Itami, Jun
Sasaki, Ryohei
Arai, Yasuaki
Sugimura, Kazuro
author_facet Watanabe, Yoshiaki
Kurihara, Hiroaki
Itami, Jun
Sasaki, Ryohei
Arai, Yasuaki
Sugimura, Kazuro
author_sort Watanabe, Yoshiaki
collection PubMed
description BACKGROUND AND PURPOSE: The purpose of this study was to determine the distribution of 4-borono-2-(18)F-fluoro-phenylalanine ((18)F-BPA) and L-[methyl-(11)C] methionine ((11)C-Met) in normal organs and tumors and to evaluate the usefulness of (11)C-Met/PET in screening potential candidates for boron neutron capture therapy (BNCT). MATERIAL METHODS: Seven patients who had at least one histologically confirmed head and neck tumor were included in this study. They underwent both whole-body (18)F-BPA-PET/CT and (11)C-Met-PET/CT within a span of 6 months. Uptake was evaluated using the maximum standardized uptake value (SUVmax). Regions of interest (ROIs) were placed within the tumors and target organs of brain, thyroid, submandibular gland, lung, liver, esophagus, stomach pancreas, spleen, muscle, and bone marrow. RESULTS: The tumor SUVmax of FBPA and (11)C-Met showed strong correlation (r (2) = 0.72, P = 0.015). Although (18)F-BPA and (11)C-Met showed markedly different uptake in some organs (submandibular gland, liver, heart, stomach pancreas, spleen, and bone marrow), the uptake of (11)C-Met was consistently higher than that of (18)F-BPA in these cases. CONCLUSION: (11)C-Met PET/CT might be used instead of (18)F-BPA PET/CT to predict the accumulation of (10)B in tumors and to select candidates for BNCT. However, it would not be suitable for evaluating accumulation in some normal organs. Therefore, the (18)F-BPA-PET study remains a prerequisite for BNCT. This is the first report of the correlation between (18)F-BPA and (11)C-Met accumulation.
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spelling pubmed-52375052017-01-18 Relationship between the uptake of (18)F-borono-L-phenylalanine and L-[methyl-(11)C] methionine in head and neck tumors and normal organs Watanabe, Yoshiaki Kurihara, Hiroaki Itami, Jun Sasaki, Ryohei Arai, Yasuaki Sugimura, Kazuro Radiat Oncol Research BACKGROUND AND PURPOSE: The purpose of this study was to determine the distribution of 4-borono-2-(18)F-fluoro-phenylalanine ((18)F-BPA) and L-[methyl-(11)C] methionine ((11)C-Met) in normal organs and tumors and to evaluate the usefulness of (11)C-Met/PET in screening potential candidates for boron neutron capture therapy (BNCT). MATERIAL METHODS: Seven patients who had at least one histologically confirmed head and neck tumor were included in this study. They underwent both whole-body (18)F-BPA-PET/CT and (11)C-Met-PET/CT within a span of 6 months. Uptake was evaluated using the maximum standardized uptake value (SUVmax). Regions of interest (ROIs) were placed within the tumors and target organs of brain, thyroid, submandibular gland, lung, liver, esophagus, stomach pancreas, spleen, muscle, and bone marrow. RESULTS: The tumor SUVmax of FBPA and (11)C-Met showed strong correlation (r (2) = 0.72, P = 0.015). Although (18)F-BPA and (11)C-Met showed markedly different uptake in some organs (submandibular gland, liver, heart, stomach pancreas, spleen, and bone marrow), the uptake of (11)C-Met was consistently higher than that of (18)F-BPA in these cases. CONCLUSION: (11)C-Met PET/CT might be used instead of (18)F-BPA PET/CT to predict the accumulation of (10)B in tumors and to select candidates for BNCT. However, it would not be suitable for evaluating accumulation in some normal organs. Therefore, the (18)F-BPA-PET study remains a prerequisite for BNCT. This is the first report of the correlation between (18)F-BPA and (11)C-Met accumulation. BioMed Central 2017-01-14 /pmc/articles/PMC5237505/ /pubmed/28088230 http://dx.doi.org/10.1186/s13014-017-0763-6 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Watanabe, Yoshiaki
Kurihara, Hiroaki
Itami, Jun
Sasaki, Ryohei
Arai, Yasuaki
Sugimura, Kazuro
Relationship between the uptake of (18)F-borono-L-phenylalanine and L-[methyl-(11)C] methionine in head and neck tumors and normal organs
title Relationship between the uptake of (18)F-borono-L-phenylalanine and L-[methyl-(11)C] methionine in head and neck tumors and normal organs
title_full Relationship between the uptake of (18)F-borono-L-phenylalanine and L-[methyl-(11)C] methionine in head and neck tumors and normal organs
title_fullStr Relationship between the uptake of (18)F-borono-L-phenylalanine and L-[methyl-(11)C] methionine in head and neck tumors and normal organs
title_full_unstemmed Relationship between the uptake of (18)F-borono-L-phenylalanine and L-[methyl-(11)C] methionine in head and neck tumors and normal organs
title_short Relationship between the uptake of (18)F-borono-L-phenylalanine and L-[methyl-(11)C] methionine in head and neck tumors and normal organs
title_sort relationship between the uptake of (18)f-borono-l-phenylalanine and l-[methyl-(11)c] methionine in head and neck tumors and normal organs
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237505/
https://www.ncbi.nlm.nih.gov/pubmed/28088230
http://dx.doi.org/10.1186/s13014-017-0763-6
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