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Correlation of SASH1 expression and ultrasonographic features in breast cancer
OBJECTIVE: SASH1 is a member of the SH3/SAM adapter molecules family and has been identified as a new tumor suppressor and critical protein in signal transduction. An ectopic expression of SASH1 is associated with decreased cell viability of breast cancer. The aim of this study was to explore the as...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237597/ https://www.ncbi.nlm.nih.gov/pubmed/28138250 http://dx.doi.org/10.2147/OTT.S119244 |
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author | Gong, Xuchu Wu, Jinna Wu, Jian Liu, Jun Gu, Hailin Shen, Hao |
author_facet | Gong, Xuchu Wu, Jinna Wu, Jian Liu, Jun Gu, Hailin Shen, Hao |
author_sort | Gong, Xuchu |
collection | PubMed |
description | OBJECTIVE: SASH1 is a member of the SH3/SAM adapter molecules family and has been identified as a new tumor suppressor and critical protein in signal transduction. An ectopic expression of SASH1 is associated with decreased cell viability of breast cancer. The aim of this study was to explore the association between SASH1 expression and the ultrasonographic features in breast cancer. PATIENTS AND METHODS: A total of 186 patients diagnosed with breast cancer were included in this study. The patients received preoperative ultrasound examination, and the expression of SASH1 was determined using immunohistochemistry methods. Spearman’s rank correlation analysis was used to analyze the correlation between SASH1-positive expression and the ultrasonographic features. RESULTS: The positive expression of SASH1 was observed in 63 (33.9%) patients. The positive expression rate of SASH1 was significantly decreased in patients with breast cancer (63/186, 33.9%) compared with controls (P<0.001). The positive expression rate of SASH1 was significantly decreased in patients with edge burr sign (P=0.025), lymph node metastasis (P=0.007), and a blood flow grade of III (P=0.013) compared with patients without those adverse ultrasonographic features. The expression of SASH1 was negatively correlated with edge burr sign (P=0.025), lymph node metastasis (P=0.007), and blood flow grade (P=0.003) of the patients with breast cancer. CONCLUSION: The expression of SASH1 was inversely correlated with some critical ultrasonographic features, including edge burr sign, lymph node metastasis, and blood flow grade in breast cancer, and decreased SASH1 expression appears to be associated with adverse clinical and imaging features in breast cancer. |
format | Online Article Text |
id | pubmed-5237597 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-52375972017-01-30 Correlation of SASH1 expression and ultrasonographic features in breast cancer Gong, Xuchu Wu, Jinna Wu, Jian Liu, Jun Gu, Hailin Shen, Hao Onco Targets Ther Original Research OBJECTIVE: SASH1 is a member of the SH3/SAM adapter molecules family and has been identified as a new tumor suppressor and critical protein in signal transduction. An ectopic expression of SASH1 is associated with decreased cell viability of breast cancer. The aim of this study was to explore the association between SASH1 expression and the ultrasonographic features in breast cancer. PATIENTS AND METHODS: A total of 186 patients diagnosed with breast cancer were included in this study. The patients received preoperative ultrasound examination, and the expression of SASH1 was determined using immunohistochemistry methods. Spearman’s rank correlation analysis was used to analyze the correlation between SASH1-positive expression and the ultrasonographic features. RESULTS: The positive expression of SASH1 was observed in 63 (33.9%) patients. The positive expression rate of SASH1 was significantly decreased in patients with breast cancer (63/186, 33.9%) compared with controls (P<0.001). The positive expression rate of SASH1 was significantly decreased in patients with edge burr sign (P=0.025), lymph node metastasis (P=0.007), and a blood flow grade of III (P=0.013) compared with patients without those adverse ultrasonographic features. The expression of SASH1 was negatively correlated with edge burr sign (P=0.025), lymph node metastasis (P=0.007), and blood flow grade (P=0.003) of the patients with breast cancer. CONCLUSION: The expression of SASH1 was inversely correlated with some critical ultrasonographic features, including edge burr sign, lymph node metastasis, and blood flow grade in breast cancer, and decreased SASH1 expression appears to be associated with adverse clinical and imaging features in breast cancer. Dove Medical Press 2017-01-10 /pmc/articles/PMC5237597/ /pubmed/28138250 http://dx.doi.org/10.2147/OTT.S119244 Text en © 2017 Gong et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Gong, Xuchu Wu, Jinna Wu, Jian Liu, Jun Gu, Hailin Shen, Hao Correlation of SASH1 expression and ultrasonographic features in breast cancer |
title | Correlation of SASH1 expression and ultrasonographic features in breast cancer |
title_full | Correlation of SASH1 expression and ultrasonographic features in breast cancer |
title_fullStr | Correlation of SASH1 expression and ultrasonographic features in breast cancer |
title_full_unstemmed | Correlation of SASH1 expression and ultrasonographic features in breast cancer |
title_short | Correlation of SASH1 expression and ultrasonographic features in breast cancer |
title_sort | correlation of sash1 expression and ultrasonographic features in breast cancer |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237597/ https://www.ncbi.nlm.nih.gov/pubmed/28138250 http://dx.doi.org/10.2147/OTT.S119244 |
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