Cargando…
Molecular mechanisms of bio-catalysis of heme extraction from hemoglobin
Red blood cell hemolysis in sickle cell disease (SCD) releases free hemoglobin. Extracellular hemoglobin and its degradation products, free heme and iron, are highly toxic due to oxidative stress induction and decrease in nitric oxide availability. We propose an approach that helps to eliminate extr...
Autores principales: | Sakipov, Serzhan, Rafikova, Olga, Kurnikova, Maria G., Rafikov, Ruslan |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237811/ https://www.ncbi.nlm.nih.gov/pubmed/28088643 http://dx.doi.org/10.1016/j.redox.2017.01.004 |
Ejemplares similares
-
Ion Permeation Mechanism in Epithelial Calcium Channel TRVP6
por: Sakipov, Serzhan, et al.
Publicado: (2018) -
Focus on Early Events: Pathogenesis of Pulmonary Arterial Hypertension Development
por: Rafikova, Olga, et al.
Publicado: (2019) -
Pulmonary Arterial Hypertension Induces a Distinct Signature of Circulating Metabolites
por: Rafikov, Ruslan, et al.
Publicado: (2020) -
Recurrent inhibition of mitochondrial complex III induces chronic pulmonary vasoconstriction and glycolytic switch in the rat lung
por: Rafikova, Olga, et al.
Publicado: (2018) -
Role of Gender in Regulation of Redox Homeostasis in Pulmonary Arterial Hypertension
por: Rafikov, Ruslan, et al.
Publicado: (2019)