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Molecular mechanisms of bio-catalysis of heme extraction from hemoglobin

Red blood cell hemolysis in sickle cell disease (SCD) releases free hemoglobin. Extracellular hemoglobin and its degradation products, free heme and iron, are highly toxic due to oxidative stress induction and decrease in nitric oxide availability. We propose an approach that helps to eliminate extr...

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Detalles Bibliográficos
Autores principales:	Sakipov, Serzhan, Rafikova, Olga, Kurnikova, Maria G., Rafikov, Ruslan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237811/ https://www.ncbi.nlm.nih.gov/pubmed/28088643 http://dx.doi.org/10.1016/j.redox.2017.01.004

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