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Mitotic catastrophe is a putative mechanism underlying the weak correlation between sensitivity to carbon ions and cisplatin
In cancer therapy today, carbon ion radiotherapy is used mainly as monotherapy, whereas cisplatin is used concomitantly with X-ray radiotherapy. The effectiveness of concomitant carbon ions and cisplatin is unclear. To obtain the information on the mechanisms potentially shared between carbon ions o...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238371/ https://www.ncbi.nlm.nih.gov/pubmed/28091564 http://dx.doi.org/10.1038/srep40588 |
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author | Kobayashi, Daijiro Oike, Takahiro Shibata, Atsushi Niimi, Atsuko Kubota, Yoshiki Sakai, Makoto Amornwhichet, Napapat Yoshimoto, Yuya Hagiwara, Yoshihiko Kimura, Yuka Hirota, Yuka Sato, Hiro Isono, Mayu Yoshida, Yukari Kohno, Takashi Ohno, Tatsuya Nakano, Takashi |
author_facet | Kobayashi, Daijiro Oike, Takahiro Shibata, Atsushi Niimi, Atsuko Kubota, Yoshiki Sakai, Makoto Amornwhichet, Napapat Yoshimoto, Yuya Hagiwara, Yoshihiko Kimura, Yuka Hirota, Yuka Sato, Hiro Isono, Mayu Yoshida, Yukari Kohno, Takashi Ohno, Tatsuya Nakano, Takashi |
author_sort | Kobayashi, Daijiro |
collection | PubMed |
description | In cancer therapy today, carbon ion radiotherapy is used mainly as monotherapy, whereas cisplatin is used concomitantly with X-ray radiotherapy. The effectiveness of concomitant carbon ions and cisplatin is unclear. To obtain the information on the mechanisms potentially shared between carbon ions or X-rays and cisplatin, we assessed the correlation of sensitivity to the single treatments. In 20 human cancer cell lines, sensitivity to X-rays strongly correlated with sensitivity to cisplatin, indicating the presence of potentially shared target mechanisms. Interestingly, the correlation of sensitivity to carbon ions and cisplatin was much weaker than that of sensitivity to X-rays and cisplatin, indicating the presence of potentially different target mechanisms between carbon ions and cisplatin. Assessment of clonogenic cell death by 4′,6-diamidino-2-phenylindole dihydrochloride staining showed that mitotic catastrophe was more efficiently induced by carbon ions than by the same physical dose of X-rays, while apoptosis and senescence were not. These data indicate that the correlation of sensitivity to carbon ions and cisplatin is weaker than that of sensitivity to X-rays and cisplatin, which are helpful as biological basis to understand the potentially shared mechanism among these treatments. Further investigation is mandatory to elucidate the clinical efficacy of carbon ions and cisplatin combination. |
format | Online Article Text |
id | pubmed-5238371 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-52383712017-01-19 Mitotic catastrophe is a putative mechanism underlying the weak correlation between sensitivity to carbon ions and cisplatin Kobayashi, Daijiro Oike, Takahiro Shibata, Atsushi Niimi, Atsuko Kubota, Yoshiki Sakai, Makoto Amornwhichet, Napapat Yoshimoto, Yuya Hagiwara, Yoshihiko Kimura, Yuka Hirota, Yuka Sato, Hiro Isono, Mayu Yoshida, Yukari Kohno, Takashi Ohno, Tatsuya Nakano, Takashi Sci Rep Article In cancer therapy today, carbon ion radiotherapy is used mainly as monotherapy, whereas cisplatin is used concomitantly with X-ray radiotherapy. The effectiveness of concomitant carbon ions and cisplatin is unclear. To obtain the information on the mechanisms potentially shared between carbon ions or X-rays and cisplatin, we assessed the correlation of sensitivity to the single treatments. In 20 human cancer cell lines, sensitivity to X-rays strongly correlated with sensitivity to cisplatin, indicating the presence of potentially shared target mechanisms. Interestingly, the correlation of sensitivity to carbon ions and cisplatin was much weaker than that of sensitivity to X-rays and cisplatin, indicating the presence of potentially different target mechanisms between carbon ions and cisplatin. Assessment of clonogenic cell death by 4′,6-diamidino-2-phenylindole dihydrochloride staining showed that mitotic catastrophe was more efficiently induced by carbon ions than by the same physical dose of X-rays, while apoptosis and senescence were not. These data indicate that the correlation of sensitivity to carbon ions and cisplatin is weaker than that of sensitivity to X-rays and cisplatin, which are helpful as biological basis to understand the potentially shared mechanism among these treatments. Further investigation is mandatory to elucidate the clinical efficacy of carbon ions and cisplatin combination. Nature Publishing Group 2017-01-16 /pmc/articles/PMC5238371/ /pubmed/28091564 http://dx.doi.org/10.1038/srep40588 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Kobayashi, Daijiro Oike, Takahiro Shibata, Atsushi Niimi, Atsuko Kubota, Yoshiki Sakai, Makoto Amornwhichet, Napapat Yoshimoto, Yuya Hagiwara, Yoshihiko Kimura, Yuka Hirota, Yuka Sato, Hiro Isono, Mayu Yoshida, Yukari Kohno, Takashi Ohno, Tatsuya Nakano, Takashi Mitotic catastrophe is a putative mechanism underlying the weak correlation between sensitivity to carbon ions and cisplatin |
title | Mitotic catastrophe is a putative mechanism underlying the weak correlation between sensitivity to carbon ions and cisplatin |
title_full | Mitotic catastrophe is a putative mechanism underlying the weak correlation between sensitivity to carbon ions and cisplatin |
title_fullStr | Mitotic catastrophe is a putative mechanism underlying the weak correlation between sensitivity to carbon ions and cisplatin |
title_full_unstemmed | Mitotic catastrophe is a putative mechanism underlying the weak correlation between sensitivity to carbon ions and cisplatin |
title_short | Mitotic catastrophe is a putative mechanism underlying the weak correlation between sensitivity to carbon ions and cisplatin |
title_sort | mitotic catastrophe is a putative mechanism underlying the weak correlation between sensitivity to carbon ions and cisplatin |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238371/ https://www.ncbi.nlm.nih.gov/pubmed/28091564 http://dx.doi.org/10.1038/srep40588 |
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