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Androgen receptor gene polymorphisms and risk of prostate cancer: a meta-analysis
Although the association between CAG and GGN repeats in the androgen receptor gene and prostate cancer risk has been widely studied, it remains controversial from previous meta-analyses and narrative reviews. Therefore, we performed this meta-analysis to provide more precise estimates with sufficien...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238402/ https://www.ncbi.nlm.nih.gov/pubmed/28091563 http://dx.doi.org/10.1038/srep40554 |
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author | Weng, Hong Li, Sheng Huang, Jing-Yu He, Zi-Qi Meng, Xiang-Yu Cao, Yue Fang, Cheng Zeng, Xian-Tao |
author_facet | Weng, Hong Li, Sheng Huang, Jing-Yu He, Zi-Qi Meng, Xiang-Yu Cao, Yue Fang, Cheng Zeng, Xian-Tao |
author_sort | Weng, Hong |
collection | PubMed |
description | Although the association between CAG and GGN repeats in the androgen receptor gene and prostate cancer risk has been widely studied, it remains controversial from previous meta-analyses and narrative reviews. Therefore, we performed this meta-analysis to provide more precise estimates with sufficient power. A total of 51 publications with 61 studies for CAG repeats and 14 publications with 16 studies for GGN repeats were identified in the meta-analysis. The results showed that short CAG repeats (<22 repeats) carriers presented an elevated risk of prostate cancer than long CAG repeats (≥22) carriers (OR = 1.31, 95% CI 1.16 to 1.47). Prostate cancer cases presented an average fewer CAG repeats (MD = −0.85, 95% CI −1.28 to −0.42) than controls. Short GGN repeats (≤16) carriers presented an increased risk of prostate cancer than long GGN repeats (>16) carriers (OR = 1.38, 95% CI 1.05 to 1.82). In subgroup analyses, the abovementioned significant association was predominantly observed in Caucasian populations. The meta-analysis showed that short CAG and GGN repeats in androgen receptor gene were associated with increased risk of prostate cancer, especially in Caucasians. |
format | Online Article Text |
id | pubmed-5238402 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-52384022017-01-19 Androgen receptor gene polymorphisms and risk of prostate cancer: a meta-analysis Weng, Hong Li, Sheng Huang, Jing-Yu He, Zi-Qi Meng, Xiang-Yu Cao, Yue Fang, Cheng Zeng, Xian-Tao Sci Rep Article Although the association between CAG and GGN repeats in the androgen receptor gene and prostate cancer risk has been widely studied, it remains controversial from previous meta-analyses and narrative reviews. Therefore, we performed this meta-analysis to provide more precise estimates with sufficient power. A total of 51 publications with 61 studies for CAG repeats and 14 publications with 16 studies for GGN repeats were identified in the meta-analysis. The results showed that short CAG repeats (<22 repeats) carriers presented an elevated risk of prostate cancer than long CAG repeats (≥22) carriers (OR = 1.31, 95% CI 1.16 to 1.47). Prostate cancer cases presented an average fewer CAG repeats (MD = −0.85, 95% CI −1.28 to −0.42) than controls. Short GGN repeats (≤16) carriers presented an increased risk of prostate cancer than long GGN repeats (>16) carriers (OR = 1.38, 95% CI 1.05 to 1.82). In subgroup analyses, the abovementioned significant association was predominantly observed in Caucasian populations. The meta-analysis showed that short CAG and GGN repeats in androgen receptor gene were associated with increased risk of prostate cancer, especially in Caucasians. Nature Publishing Group 2017-01-16 /pmc/articles/PMC5238402/ /pubmed/28091563 http://dx.doi.org/10.1038/srep40554 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Weng, Hong Li, Sheng Huang, Jing-Yu He, Zi-Qi Meng, Xiang-Yu Cao, Yue Fang, Cheng Zeng, Xian-Tao Androgen receptor gene polymorphisms and risk of prostate cancer: a meta-analysis |
title | Androgen receptor gene polymorphisms and risk of prostate cancer: a meta-analysis |
title_full | Androgen receptor gene polymorphisms and risk of prostate cancer: a meta-analysis |
title_fullStr | Androgen receptor gene polymorphisms and risk of prostate cancer: a meta-analysis |
title_full_unstemmed | Androgen receptor gene polymorphisms and risk of prostate cancer: a meta-analysis |
title_short | Androgen receptor gene polymorphisms and risk of prostate cancer: a meta-analysis |
title_sort | androgen receptor gene polymorphisms and risk of prostate cancer: a meta-analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238402/ https://www.ncbi.nlm.nih.gov/pubmed/28091563 http://dx.doi.org/10.1038/srep40554 |
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