Functional analysis reveals that RBM10 mutations contribute to lung adenocarcinoma pathogenesis by deregulating splicing

RBM10 is an RNA splicing regulator that is frequently mutated in lung adenocarcinoma (LUAD) and has recently been proposed to be a cancer gene. How RBM10 mutations observed in LUAD affect its normal functions, however, remains largely unknown. Here integrative analysis of RBM10 mutation and RNA expr...

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Detalles Bibliográficos
Autores principales: Zhao, Jiawei, Sun, Yue, Huang, Yin, Song, Fan, Huang, Zengshu, Bao, Yufang, Zuo, Ji, Saffen, David, Shao, Zhen, Liu, Wen, Wang, Yongbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238425/
https://www.ncbi.nlm.nih.gov/pubmed/28091594
http://dx.doi.org/10.1038/srep40488

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238425/
https://www.ncbi.nlm.nih.gov/pubmed/28091594
http://dx.doi.org/10.1038/srep40488

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