Simple, Efficient and Controllable Synthesis of Iodo/Di-iodoarenes via Ipsoiododecarboxylation/Consecutive Iodination Strategy

A practical, efficient, and operationally simple strategy for the ipsoiododecarboxylation and di-iodination of aromatic carboxylic acids using the low-cost commercial reagent succinimide (NIS) as iodine source is reported. This iodination or di-iodination process can be easily controlled through rea...

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Detalles Bibliográficos
Autores principales: Yang, Yun, Zhang, Lijuan, Deng, Guo-Jun, Gong, Hang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238447/
https://www.ncbi.nlm.nih.gov/pubmed/28091536
http://dx.doi.org/10.1038/srep40430
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author Yang, Yun
Zhang, Lijuan
Deng, Guo-Jun
Gong, Hang
author_facet Yang, Yun
Zhang, Lijuan
Deng, Guo-Jun
Gong, Hang
author_sort Yang, Yun
collection PubMed
description A practical, efficient, and operationally simple strategy for the ipsoiododecarboxylation and di-iodination of aromatic carboxylic acids using the low-cost commercial reagent succinimide (NIS) as iodine source is reported. This iodination or di-iodination process can be easily controlled through reaction conditions, thereby providing corresponding iodination or di-iodination products with high yields. Furthermore, these two reactions can be easily scaled up to gram-scale by using palladium catalyst (0.66 mol%), which provides high isolated yield.
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spelling pubmed-52384472017-01-19 Simple, Efficient and Controllable Synthesis of Iodo/Di-iodoarenes via Ipsoiododecarboxylation/Consecutive Iodination Strategy Yang, Yun Zhang, Lijuan Deng, Guo-Jun Gong, Hang Sci Rep Article A practical, efficient, and operationally simple strategy for the ipsoiododecarboxylation and di-iodination of aromatic carboxylic acids using the low-cost commercial reagent succinimide (NIS) as iodine source is reported. This iodination or di-iodination process can be easily controlled through reaction conditions, thereby providing corresponding iodination or di-iodination products with high yields. Furthermore, these two reactions can be easily scaled up to gram-scale by using palladium catalyst (0.66 mol%), which provides high isolated yield. Nature Publishing Group 2017-01-16 /pmc/articles/PMC5238447/ /pubmed/28091536 http://dx.doi.org/10.1038/srep40430 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Yang, Yun
Zhang, Lijuan
Deng, Guo-Jun
Gong, Hang
Simple, Efficient and Controllable Synthesis of Iodo/Di-iodoarenes via Ipsoiododecarboxylation/Consecutive Iodination Strategy
title Simple, Efficient and Controllable Synthesis of Iodo/Di-iodoarenes via Ipsoiododecarboxylation/Consecutive Iodination Strategy
title_full Simple, Efficient and Controllable Synthesis of Iodo/Di-iodoarenes via Ipsoiododecarboxylation/Consecutive Iodination Strategy
title_fullStr Simple, Efficient and Controllable Synthesis of Iodo/Di-iodoarenes via Ipsoiododecarboxylation/Consecutive Iodination Strategy
title_full_unstemmed Simple, Efficient and Controllable Synthesis of Iodo/Di-iodoarenes via Ipsoiododecarboxylation/Consecutive Iodination Strategy
title_short Simple, Efficient and Controllable Synthesis of Iodo/Di-iodoarenes via Ipsoiododecarboxylation/Consecutive Iodination Strategy
title_sort simple, efficient and controllable synthesis of iodo/di-iodoarenes via ipsoiododecarboxylation/consecutive iodination strategy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238447/
https://www.ncbi.nlm.nih.gov/pubmed/28091536
http://dx.doi.org/10.1038/srep40430
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