The weight of flash chromatography: A tool to predict its mass intensity from thin-layer chromatography

Purification by flash chromatography strongly impacts the greenness of a process. Unfortunately, due to the lack of the relevant literature data, very often this impact cannot be assessed thus preventing the comparison of the environmental factors affecting the syntheses. We developed a simple mathe...

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Detalles Bibliográficos
Autores principales: Pessel, Freddy, Augé, Jacques, Billault, Isabelle, Scherrmann, Marie-Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2016
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238533/
https://www.ncbi.nlm.nih.gov/pubmed/28144302
http://dx.doi.org/10.3762/bjoc.12.228
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author Pessel, Freddy
Augé, Jacques
Billault, Isabelle
Scherrmann, Marie-Christine
author_facet Pessel, Freddy
Augé, Jacques
Billault, Isabelle
Scherrmann, Marie-Christine
author_sort Pessel, Freddy
collection PubMed
description Purification by flash chromatography strongly impacts the greenness of a process. Unfortunately, due to the lack of the relevant literature data, very often this impact cannot be assessed thus preventing the comparison of the environmental factors affecting the syntheses. We developed a simple mathematical approach to evaluate the minimum mass intensity of flash chromatography from the retention factor values determined by thin-layer chromatography.
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spelling pubmed-52385332017-01-31 The weight of flash chromatography: A tool to predict its mass intensity from thin-layer chromatography Pessel, Freddy Augé, Jacques Billault, Isabelle Scherrmann, Marie-Christine Beilstein J Org Chem Full Research Paper Purification by flash chromatography strongly impacts the greenness of a process. Unfortunately, due to the lack of the relevant literature data, very often this impact cannot be assessed thus preventing the comparison of the environmental factors affecting the syntheses. We developed a simple mathematical approach to evaluate the minimum mass intensity of flash chromatography from the retention factor values determined by thin-layer chromatography. Beilstein-Institut 2016-11-08 /pmc/articles/PMC5238533/ /pubmed/28144302 http://dx.doi.org/10.3762/bjoc.12.228 Text en Copyright © 2016, Pessel et al. https://creativecommons.org/licenses/by/4.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Pessel, Freddy
Augé, Jacques
Billault, Isabelle
Scherrmann, Marie-Christine
The weight of flash chromatography: A tool to predict its mass intensity from thin-layer chromatography
title The weight of flash chromatography: A tool to predict its mass intensity from thin-layer chromatography
title_full The weight of flash chromatography: A tool to predict its mass intensity from thin-layer chromatography
title_fullStr The weight of flash chromatography: A tool to predict its mass intensity from thin-layer chromatography
title_full_unstemmed The weight of flash chromatography: A tool to predict its mass intensity from thin-layer chromatography
title_short The weight of flash chromatography: A tool to predict its mass intensity from thin-layer chromatography
title_sort weight of flash chromatography: a tool to predict its mass intensity from thin-layer chromatography
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238533/
https://www.ncbi.nlm.nih.gov/pubmed/28144302
http://dx.doi.org/10.3762/bjoc.12.228
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