Poly(ethylene glycol)s as grinding additives in the mechanochemical preparation of highly functionalized 3,5-disubstituted hydantoins

The mechanochemical preparation of highly functionalized 3,5-disubstituted hydantoins was investigated in the presence of various poly(ethylene) glycols (PEGs), as safe grinding assisting agents (liquid-assisted grinding, LAG). A comparative study under dry-grinding conditions was also performed. Th...

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Detalles Bibliográficos
Autores principales: Mascitti, Andrea, Lupacchini, Massimiliano, Guerra, Ruben, Taydakov, Ilya, Tonucci, Lucia, d’Alessandro, Nicola, Lamaty, Frederic, Martinez, Jean, Colacino, Evelina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2017
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238572/
https://www.ncbi.nlm.nih.gov/pubmed/28179944
http://dx.doi.org/10.3762/bjoc.13.3
Descripción
Sumario:The mechanochemical preparation of highly functionalized 3,5-disubstituted hydantoins was investigated in the presence of various poly(ethylene) glycols (PEGs), as safe grinding assisting agents (liquid-assisted grinding, LAG). A comparative study under dry-grinding conditions was also performed. The results showed that the cyclization reaction was influenced by the amount of the PEG grinding agents. In general, cleaner reaction profiles were observed in the presence of PEGs, compared to dry-grinding procedures.

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