Poly(ethylene glycol)s as grinding additives in the mechanochemical preparation of highly functionalized 3,5-disubstituted hydantoins

The mechanochemical preparation of highly functionalized 3,5-disubstituted hydantoins was investigated in the presence of various poly(ethylene) glycols (PEGs), as safe grinding assisting agents (liquid-assisted grinding, LAG). A comparative study under dry-grinding conditions was also performed. Th...

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Autores principales: Mascitti, Andrea, Lupacchini, Massimiliano, Guerra, Ruben, Taydakov, Ilya, Tonucci, Lucia, d’Alessandro, Nicola, Lamaty, Frederic, Martinez, Jean, Colacino, Evelina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2017
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238572/
https://www.ncbi.nlm.nih.gov/pubmed/28179944
http://dx.doi.org/10.3762/bjoc.13.3
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author Mascitti, Andrea
Lupacchini, Massimiliano
Guerra, Ruben
Taydakov, Ilya
Tonucci, Lucia
d’Alessandro, Nicola
Lamaty, Frederic
Martinez, Jean
Colacino, Evelina
author_facet Mascitti, Andrea
Lupacchini, Massimiliano
Guerra, Ruben
Taydakov, Ilya
Tonucci, Lucia
d’Alessandro, Nicola
Lamaty, Frederic
Martinez, Jean
Colacino, Evelina
author_sort Mascitti, Andrea
collection PubMed
description The mechanochemical preparation of highly functionalized 3,5-disubstituted hydantoins was investigated in the presence of various poly(ethylene) glycols (PEGs), as safe grinding assisting agents (liquid-assisted grinding, LAG). A comparative study under dry-grinding conditions was also performed. The results showed that the cyclization reaction was influenced by the amount of the PEG grinding agents. In general, cleaner reaction profiles were observed in the presence of PEGs, compared to dry-grinding procedures.
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spelling pubmed-52385722017-02-08 Poly(ethylene glycol)s as grinding additives in the mechanochemical preparation of highly functionalized 3,5-disubstituted hydantoins Mascitti, Andrea Lupacchini, Massimiliano Guerra, Ruben Taydakov, Ilya Tonucci, Lucia d’Alessandro, Nicola Lamaty, Frederic Martinez, Jean Colacino, Evelina Beilstein J Org Chem Full Research Paper The mechanochemical preparation of highly functionalized 3,5-disubstituted hydantoins was investigated in the presence of various poly(ethylene) glycols (PEGs), as safe grinding assisting agents (liquid-assisted grinding, LAG). A comparative study under dry-grinding conditions was also performed. The results showed that the cyclization reaction was influenced by the amount of the PEG grinding agents. In general, cleaner reaction profiles were observed in the presence of PEGs, compared to dry-grinding procedures. Beilstein-Institut 2017-01-04 /pmc/articles/PMC5238572/ /pubmed/28179944 http://dx.doi.org/10.3762/bjoc.13.3 Text en Copyright © 2017, Mascitti et al. https://creativecommons.org/licenses/by/4.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Mascitti, Andrea
Lupacchini, Massimiliano
Guerra, Ruben
Taydakov, Ilya
Tonucci, Lucia
d’Alessandro, Nicola
Lamaty, Frederic
Martinez, Jean
Colacino, Evelina
Poly(ethylene glycol)s as grinding additives in the mechanochemical preparation of highly functionalized 3,5-disubstituted hydantoins
title Poly(ethylene glycol)s as grinding additives in the mechanochemical preparation of highly functionalized 3,5-disubstituted hydantoins
title_full Poly(ethylene glycol)s as grinding additives in the mechanochemical preparation of highly functionalized 3,5-disubstituted hydantoins
title_fullStr Poly(ethylene glycol)s as grinding additives in the mechanochemical preparation of highly functionalized 3,5-disubstituted hydantoins
title_full_unstemmed Poly(ethylene glycol)s as grinding additives in the mechanochemical preparation of highly functionalized 3,5-disubstituted hydantoins
title_short Poly(ethylene glycol)s as grinding additives in the mechanochemical preparation of highly functionalized 3,5-disubstituted hydantoins
title_sort poly(ethylene glycol)s as grinding additives in the mechanochemical preparation of highly functionalized 3,5-disubstituted hydantoins
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238572/
https://www.ncbi.nlm.nih.gov/pubmed/28179944
http://dx.doi.org/10.3762/bjoc.13.3
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