Cargando…
Biochemical and structural characterisation of the second oxidative crosslinking step during the biosynthesis of the glycopeptide antibiotic A47934
The chemical complexity and biological activity of the glycopeptide antibiotics (GPAs) stems from their unique crosslinked structure, which is generated by the actions of cytochrome P450 (Oxy) enzymes that affect the crosslinking of aromatic side chains of amino acid residues contained within the GP...
Autores principales: | Ulrich, Veronika, Brieke, Clara, Cryle, Max J |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Beilstein-Institut
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238595/ https://www.ncbi.nlm.nih.gov/pubmed/28144358 http://dx.doi.org/10.3762/bjoc.12.284 |
Ejemplares similares
-
F-O-G Ring Formation in Glycopeptide Antibiotic Biosynthesis is Catalysed by OxyE
por: Peschke, Madeleine, et al.
Publicado: (2016) -
Genome Sequence of Streptomyces toyocaensis NRRL 15009, Producer of the Glycopeptide Antibiotic A47934
por: Kwun, Min Jung, et al.
Publicado: (2014) -
Kistamicin biosynthesis reveals the biosynthetic requirements for production of highly crosslinked glycopeptide antibiotics
por: Greule, Anja, et al.
Publicado: (2019) -
The biosynthetic implications of late-stage condensation domain selectivity during glycopeptide antibiotic biosynthesis
por: Schoppet, Melanie, et al.
Publicado: (2018) -
The Diiron Monooxygenase
CmlA from Chloramphenicol
Biosynthesis Allows Reconstitution of β-Hydroxylation
during Glycopeptide Antibiotic Biosynthesis
por: Kaniusaite, Milda, et al.
Publicado: (2019)