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PDX1 dynamically regulates pancreatic ductal adenocarcinoma initiation and maintenance

Aberrant activation of embryonic signaling pathways is frequent in pancreatic ductal adenocarcinoma (PDA), making developmental regulators therapeutically attractive. Here we demonstrate diverse functions for pancreatic and duodenal homeobox 1 (PDX1), a transcription factor indispensable for pancrea...

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Detalles Bibliográficos
Autores principales:	Roy, Nilotpal, Takeuchi, Kenneth K., Ruggeri, Jeanine M., Bailey, Peter, Chang, David, Li, Joey, Leonhardt, Laura, Puri, Sapna, Hoffman, Megan T., Gao, Shan, Halbrook, Christopher J., Song, Yan, Ljungman, Mats, Malik, Shivani, Wright, Christopher V.E., Dawson, David W., Biankin, Andrew V., Hebrok, Matthias, Crawford, Howard C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238727/ https://www.ncbi.nlm.nih.gov/pubmed/28087712 http://dx.doi.org/10.1101/gad.291021.116

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