United we stand: big roles for small RNA gene clusters

Prokaryotes and eukaryotes evolved relatively similar RNA-based molecular mechanisms to fight potentially deleterious nucleic acids coming from phages, transposons, or viruses. Short RNAs guide effector complexes toward their targets to be silenced or eliminated. These short immunity RNAs are transc...

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Detalles Bibliográficos
Autores principales: Felden, Brice, Paillard, Luc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238787/
https://www.ncbi.nlm.nih.gov/pubmed/27881475
http://dx.doi.org/10.1261/rna.058891.116
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author Felden, Brice
Paillard, Luc
author_facet Felden, Brice
Paillard, Luc
author_sort Felden, Brice
collection PubMed
description Prokaryotes and eukaryotes evolved relatively similar RNA-based molecular mechanisms to fight potentially deleterious nucleic acids coming from phages, transposons, or viruses. Short RNAs guide effector complexes toward their targets to be silenced or eliminated. These short immunity RNAs are transcribed from clustered loci. Unexpectedly and strikingly, bacterial and eukaryotic immunity RNA clusters share substantial functional and mechanistic resemblances in fighting nucleic acid intruders.
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spelling pubmed-52387872018-02-01 United we stand: big roles for small RNA gene clusters Felden, Brice Paillard, Luc RNA Perspective Prokaryotes and eukaryotes evolved relatively similar RNA-based molecular mechanisms to fight potentially deleterious nucleic acids coming from phages, transposons, or viruses. Short RNAs guide effector complexes toward their targets to be silenced or eliminated. These short immunity RNAs are transcribed from clustered loci. Unexpectedly and strikingly, bacterial and eukaryotic immunity RNA clusters share substantial functional and mechanistic resemblances in fighting nucleic acid intruders. Cold Spring Harbor Laboratory Press 2017-02 /pmc/articles/PMC5238787/ /pubmed/27881475 http://dx.doi.org/10.1261/rna.058891.116 Text en © 2017 Felden and Paillard; Published by Cold Spring Harbor Laboratory Press for the RNA Society http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by the RNA Society for the first 12 months after the full-issue publication date (see http://rnajournal.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Perspective
Felden, Brice
Paillard, Luc
United we stand: big roles for small RNA gene clusters
title United we stand: big roles for small RNA gene clusters
title_full United we stand: big roles for small RNA gene clusters
title_fullStr United we stand: big roles for small RNA gene clusters
title_full_unstemmed United we stand: big roles for small RNA gene clusters
title_short United we stand: big roles for small RNA gene clusters
title_sort united we stand: big roles for small rna gene clusters
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238787/
https://www.ncbi.nlm.nih.gov/pubmed/27881475
http://dx.doi.org/10.1261/rna.058891.116
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