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Induced fit of the peptidyl-transferase center of the ribosome and conformational freedom of the esterified amino acids
The catalytic site of most enzymes can efficiently handle only one substrate. In contrast, the ribosome is capable of polymerizing at a similar rate at least 20 different kinds of amino acids from aminoacyl-tRNA carriers while using just one catalytic site, the peptidyl-transferase center (PTC). An...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory Press
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238797/ https://www.ncbi.nlm.nih.gov/pubmed/27879432 http://dx.doi.org/10.1261/rna.057273.116 |