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Six plant extracts delay yeast chronological aging through different signaling pathways

Our recent study has revealed six plant extracts that slow yeast chronological aging more efficiently than any chemical compound yet described. The rate of aging in yeast is controlled by an evolutionarily conserved network of integrated signaling pathways and protein kinases. Here, we assessed how...

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Autores principales: Lutchman, Vicky, Dakik, Pamela, McAuley, Mélissa, Cortes, Berly, Ferraye, George, Gontmacher, Leonid, Graziano, David, Moukhariq, Fatima-Zohra, Simard, Éric, Titorenko, Vladimir I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239441/
https://www.ncbi.nlm.nih.gov/pubmed/27447556
http://dx.doi.org/10.18632/oncotarget.10689
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author Lutchman, Vicky
Dakik, Pamela
McAuley, Mélissa
Cortes, Berly
Ferraye, George
Gontmacher, Leonid
Graziano, David
Moukhariq, Fatima-Zohra
Simard, Éric
Titorenko, Vladimir I.
author_facet Lutchman, Vicky
Dakik, Pamela
McAuley, Mélissa
Cortes, Berly
Ferraye, George
Gontmacher, Leonid
Graziano, David
Moukhariq, Fatima-Zohra
Simard, Éric
Titorenko, Vladimir I.
author_sort Lutchman, Vicky
collection PubMed
description Our recent study has revealed six plant extracts that slow yeast chronological aging more efficiently than any chemical compound yet described. The rate of aging in yeast is controlled by an evolutionarily conserved network of integrated signaling pathways and protein kinases. Here, we assessed how single-gene-deletion mutations eliminating each of these pathways and kinases affect the aging-delaying efficiencies of the six plant extracts. Our findings imply that these extracts slow aging in the following ways: 1) plant extract 4 decreases the efficiency with which the pro-aging TORC1 pathway inhibits the anti-aging SNF1 pathway; 2) plant extract 5 mitigates two different branches of the pro-aging PKA pathway; 3) plant extract 6 coordinates processes that are not assimilated into the network of presently known signaling pathways/protein kinases; 4) plant extract 8 diminishes the inhibitory action of PKA on SNF1; 5) plant extract 12 intensifies the anti-aging protein kinase Rim15; and 6) plant extract 21 inhibits a form of the pro-aging protein kinase Sch9 that is activated by the pro-aging PKH1/2 pathway.
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spelling pubmed-52394412017-01-24 Six plant extracts delay yeast chronological aging through different signaling pathways Lutchman, Vicky Dakik, Pamela McAuley, Mélissa Cortes, Berly Ferraye, George Gontmacher, Leonid Graziano, David Moukhariq, Fatima-Zohra Simard, Éric Titorenko, Vladimir I. Oncotarget Research Paper: Gerotarget (Focus on Aging) Our recent study has revealed six plant extracts that slow yeast chronological aging more efficiently than any chemical compound yet described. The rate of aging in yeast is controlled by an evolutionarily conserved network of integrated signaling pathways and protein kinases. Here, we assessed how single-gene-deletion mutations eliminating each of these pathways and kinases affect the aging-delaying efficiencies of the six plant extracts. Our findings imply that these extracts slow aging in the following ways: 1) plant extract 4 decreases the efficiency with which the pro-aging TORC1 pathway inhibits the anti-aging SNF1 pathway; 2) plant extract 5 mitigates two different branches of the pro-aging PKA pathway; 3) plant extract 6 coordinates processes that are not assimilated into the network of presently known signaling pathways/protein kinases; 4) plant extract 8 diminishes the inhibitory action of PKA on SNF1; 5) plant extract 12 intensifies the anti-aging protein kinase Rim15; and 6) plant extract 21 inhibits a form of the pro-aging protein kinase Sch9 that is activated by the pro-aging PKH1/2 pathway. Impact Journals LLC 2016-07-18 /pmc/articles/PMC5239441/ /pubmed/27447556 http://dx.doi.org/10.18632/oncotarget.10689 Text en Copyright: © 2016 Lutchman et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper: Gerotarget (Focus on Aging)
Lutchman, Vicky
Dakik, Pamela
McAuley, Mélissa
Cortes, Berly
Ferraye, George
Gontmacher, Leonid
Graziano, David
Moukhariq, Fatima-Zohra
Simard, Éric
Titorenko, Vladimir I.
Six plant extracts delay yeast chronological aging through different signaling pathways
title Six plant extracts delay yeast chronological aging through different signaling pathways
title_full Six plant extracts delay yeast chronological aging through different signaling pathways
title_fullStr Six plant extracts delay yeast chronological aging through different signaling pathways
title_full_unstemmed Six plant extracts delay yeast chronological aging through different signaling pathways
title_short Six plant extracts delay yeast chronological aging through different signaling pathways
title_sort six plant extracts delay yeast chronological aging through different signaling pathways
topic Research Paper: Gerotarget (Focus on Aging)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239441/
https://www.ncbi.nlm.nih.gov/pubmed/27447556
http://dx.doi.org/10.18632/oncotarget.10689
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