Recurrent, truncating SOX9 mutations are associated with SOX9 overexpression, KRAS mutation, and TP53 wild type status in colorectal carcinoma

PURPOSE: The extent to which the developmental transcription factor SOX9 functions as an oncogene or tumor suppressor in colorectal carcinoma (CRC) is debatable. We aimed to clarify the effect of SOX9 mutations on SOX9 protein expression and their association with known molecular subtypes and clinic...

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Detalles Bibliográficos
Autores principales: Javier, Breanna M., Yaeger, Rona, Wang, Lu, Sanchez-Vega, Francisco, Zehir, Ahmet, Middha, Sumit, Sadowska, Justyna, Vakiani, Efsevia, Shia, Jinru, Klimstra, David, Ladanyi, Marc, Iacobuzio-Donahue, Christine A., Hechtman, Jaclyn F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper: Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239443/
https://www.ncbi.nlm.nih.gov/pubmed/27248473
http://dx.doi.org/10.18632/oncotarget.9682

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