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Nomograms predicting long-term overall survival and cancer-specific survival in head and neck squamous cell carcinoma patients
This study aimed to develop nomograms to predict long-term overall survival and cancer-specific survival in patients with head and neck squamous cell carcinoma (HNSCC). We conducted prognostic analyses and developed nomograms predicting survival outcome using HNSCC patient data collected from the Su...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239458/ https://www.ncbi.nlm.nih.gov/pubmed/27419636 http://dx.doi.org/10.18632/oncotarget.10595 |
_version_ | 1782495898078543872 |
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author | Ju, Jun Wang, Jia Ma, Chao Li, Yun Zhao, Zhenyan Gao, Tao Ni, Qianwei Sun, Moyi |
author_facet | Ju, Jun Wang, Jia Ma, Chao Li, Yun Zhao, Zhenyan Gao, Tao Ni, Qianwei Sun, Moyi |
author_sort | Ju, Jun |
collection | PubMed |
description | This study aimed to develop nomograms to predict long-term overall survival and cancer-specific survival in patients with head and neck squamous cell carcinoma (HNSCC). We conducted prognostic analyses and developed nomograms predicting survival outcome using HNSCC patient data collected from the Surveillance, Epidemiology and End Results (SEER) program of the National Cancer Institute. An external dataset of 219 patients was used to validate the nomograms. Of 36,179 HNSCC patients, 9,627 (26.6%) died from HNSCC and 4,229 (11.7%) died from other causes. Median follow-up was 28 months (1-107 months). Nomograms predicting overall survival (OS) and cancer-specific survival (CSS) were developed according to 10 clinicopathologic factors (age, race, sex, tumor site, tumor grade, surgery, radiotherapy and TNM stage), with concordance indexes (C-indexes) of 0.719 and 0.741, respectively. External validation C-indexes were 0.709 and 0.706 for OS and CSS, respectively. Our results suggest that we successfully developed nomograms predicting five- and eight-year HNSCC patient OS and CSS with high accuracy. These nomograms could help clinicians tailor surgical, adjuvant therapeutic and follow-up strategies to more effectively treat HNSCC patients. |
format | Online Article Text |
id | pubmed-5239458 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-52394582017-01-24 Nomograms predicting long-term overall survival and cancer-specific survival in head and neck squamous cell carcinoma patients Ju, Jun Wang, Jia Ma, Chao Li, Yun Zhao, Zhenyan Gao, Tao Ni, Qianwei Sun, Moyi Oncotarget Research Paper This study aimed to develop nomograms to predict long-term overall survival and cancer-specific survival in patients with head and neck squamous cell carcinoma (HNSCC). We conducted prognostic analyses and developed nomograms predicting survival outcome using HNSCC patient data collected from the Surveillance, Epidemiology and End Results (SEER) program of the National Cancer Institute. An external dataset of 219 patients was used to validate the nomograms. Of 36,179 HNSCC patients, 9,627 (26.6%) died from HNSCC and 4,229 (11.7%) died from other causes. Median follow-up was 28 months (1-107 months). Nomograms predicting overall survival (OS) and cancer-specific survival (CSS) were developed according to 10 clinicopathologic factors (age, race, sex, tumor site, tumor grade, surgery, radiotherapy and TNM stage), with concordance indexes (C-indexes) of 0.719 and 0.741, respectively. External validation C-indexes were 0.709 and 0.706 for OS and CSS, respectively. Our results suggest that we successfully developed nomograms predicting five- and eight-year HNSCC patient OS and CSS with high accuracy. These nomograms could help clinicians tailor surgical, adjuvant therapeutic and follow-up strategies to more effectively treat HNSCC patients. Impact Journals LLC 2016-07-13 /pmc/articles/PMC5239458/ /pubmed/27419636 http://dx.doi.org/10.18632/oncotarget.10595 Text en Copyright: © 2016 Ju et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Ju, Jun Wang, Jia Ma, Chao Li, Yun Zhao, Zhenyan Gao, Tao Ni, Qianwei Sun, Moyi Nomograms predicting long-term overall survival and cancer-specific survival in head and neck squamous cell carcinoma patients |
title | Nomograms predicting long-term overall survival and cancer-specific survival in head and neck squamous cell carcinoma patients |
title_full | Nomograms predicting long-term overall survival and cancer-specific survival in head and neck squamous cell carcinoma patients |
title_fullStr | Nomograms predicting long-term overall survival and cancer-specific survival in head and neck squamous cell carcinoma patients |
title_full_unstemmed | Nomograms predicting long-term overall survival and cancer-specific survival in head and neck squamous cell carcinoma patients |
title_short | Nomograms predicting long-term overall survival and cancer-specific survival in head and neck squamous cell carcinoma patients |
title_sort | nomograms predicting long-term overall survival and cancer-specific survival in head and neck squamous cell carcinoma patients |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239458/ https://www.ncbi.nlm.nih.gov/pubmed/27419636 http://dx.doi.org/10.18632/oncotarget.10595 |
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