Cargando…

The ratio of STAT1 to STAT3 expression is a determinant of colorectal cancer growth

The role of STAT1 and STAT3 for colorectal carcinoma (CRC) development and progression is controversial. We evaluated 414 CRC patient samples on tissue microarrays for differential expression of STAT1 and STAT3 protein levels and correlated ratios with clinical parameters. Concomitant absence of nuc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nivarthi, Harini, Gordziel, Claire, Themanns, Madeleine, Kramer, Nina, Eberl, Markus, Rabe, Björn, Schlederer, Michaela, Rose-John, Stefan, Knösel, Thomas, Kenner, Lukas, Freund, Patricia, Aberger, Fritz, Han, Xiaonan, Kralovics, Robert, Dolznig, Helmut, Jennek, Susanne, Friedrich, Karlheinz, Moriggl, Richard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239461/ https://www.ncbi.nlm.nih.gov/pubmed/27191495 http://dx.doi.org/10.18632/oncotarget.9315

Ejemplares similares

Correction: The ratio of STAT1 to STAT3 expression is a determinant of colorectal cancer growth
por: Nivarthi, Harini, et al.
Publicado: (2018)

Both STAT1 and STAT3 are favourable prognostic determinants in colorectal carcinoma
por: Gordziel, C, et al.
Publicado: (2013)

Adipocyte STAT5 deficiency promotes adiposity and impairs lipid mobilisation in mice
por: Kaltenecker, Doris, et al.
Publicado: (2016)

STAT1 is a sex‐specific tumor suppressor in colitis‐associated colorectal cancer
por: Crnčec, Ilija, et al.
Publicado: (2018)

Monogenic deficiency in murine intestinal Cdc42 leads to mucosal inflammation that induces crypt dysplasia
por: Zhang, Dongsheng, et al.
Publicado: (2023)

Lung Adenocarcinomas and Lung Cancer Cell Lines Show Association of MMP-1 Expression With STAT3 Activation()
por: Schütz, Alexander, et al.
Publicado: (2015)

Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis
por: Grabner, Beatrice, et al.
Publicado: (2015)

High activation of STAT5A drives peripheral T-cell lymphoma and leukemia
por: Maurer, Barbara, et al.
Publicado: (2020)

STAT3 regulated ARF expression suppresses prostate cancer metastasis
por: Pencik, Jan, et al.
Publicado: (2015)

Reliable Quantification of Protein Expression and Cellular Localization in Histological Sections
por: Schlederer, Michaela, et al.
Publicado: (2014)

Erratum: STAT3 regulated ARF expression suppresses prostate cancer metastasis
por: Pencik, Jan, et al.
Publicado: (2015)

Opioids drive breast cancer metastasis through the δ-opioid receptor and oncogenic STAT3
por: Tripolt, Sabrina, et al.
Publicado: (2021)

Activated STAT5 Confers Resistance to Intestinal Injury by Increasing Intestinal Stem Cell Proliferation and Regeneration
por: Gilbert, Shila, et al.
Publicado: (2015)

STAT5B(N642H) is a driver mutation for T cell neoplasia
por: Pham, Ha Thi Thanh, et al.
Publicado: (2017)

SIAH2 antagonizes TYK2-STAT3 signaling in lung carcinoma cells
por: Müller, Sylvia, et al.
Publicado: (2014)

Acetylation and sumoylation control STAT5 activation antagonistically
por: Krämer, Oliver H., et al.
Publicado: (2012)

Targeting STAT3 and STAT5 in Cancer
por: de Araujo, Elvin D., et al.
Publicado: (2020)

Implications of STAT3 and STAT5 signaling on gene regulation and chromatin remodeling in hematopoietic cancer
por: Wingelhofer, Bettina, et al.
Publicado: (2018)

STAT3 promotes melanoma metastasis by CEBP-induced repression of the MITF pathway
por: Swoboda, Alexander, et al.
Publicado: (2021)

A centric view of JAK/STAT5 in intestinal homeostasis, infection, and inflammation
por: Surbek, Marta, et al.
Publicado: (2021)

Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma
por: Prutsch, Nicole, et al.
Publicado: (2018)

Cancer-associated fibroblast-derived WNT2 increases tumor angiogenesis in colon cancer
por: Unterleuthner, Daniela, et al.
Publicado: (2019)

O-GlcNAcylation of STAT5 controls tyrosine phosphorylation and oncogenic transcription in STAT5-dependent malignancies
por: Freund, P, et al.
Publicado: (2017)

STAT5 is Expressed in CD34(+)/CD38(−) Stem Cells and Serves as a Potential Molecular Target in Ph-Negative Myeloproliferative Neoplasms
por: Hadzijusufovic, Emir, et al.
Publicado: (2020)

Correction: Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma
por: Prutsch, Nicole, et al.
Publicado: (2020)

Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation
por: Javaheri, Tahereh, et al.
Publicado: (2016)

Correction: Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation
por: Javaheri, Tahereh, et al.
Publicado: (2018)

Retraction Note: Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation
por: Javaheri, Tahereh, et al.
Publicado: (2019)

Direct Targeting Options for STAT3 and STAT5 in Cancer
por: Orlova, Anna, et al.
Publicado: (2019)

STAT3‐dependent analysis reveals PDK4 as independent predictor of recurrence in prostate cancer
por: Oberhuber, Monika, et al.
Publicado: (2020)

The Oncogene AF1Q is Associated with WNT and STAT Signaling and Offers a Novel Independent Prognostic Marker in Patients with Resectable Esophageal Cancer
por: Gruber, Elisabeth S., et al.
Publicado: (2019)

STAT5 is required for lipid breakdown and beta-adrenergic responsiveness of brown adipose tissue
por: Kaltenecker, Doris, et al.
Publicado: (2020)

PDGFRβ promotes oncogenic progression via STAT3/STAT5 hyperactivation in anaplastic large cell lymphoma
por: Garces de los Fayos Alonso, I., et al.
Publicado: (2022)

Structural Implications of STAT3 and STAT5 SH2 Domain Mutations
por: de Araujo, Elvin D., et al.
Publicado: (2019)

Myeloid STAT3 promotes formation of colitis-associated colorectal cancer in mice
por: Pathria, Paulina, et al.
Publicado: (2015)

c-Met expression and activity in urogenital cancers – novel aspects of signal transduction and medical implications
por: Hass, Ralf, et al.
Publicado: (2017)

Synergistic cross‐talk of hedgehog and interleukin‐6 signaling drives growth of basal cell carcinoma
por: Sternberg, Christina, et al.
Publicado: (2018)

Loss of STAT3 in Lymphoma Relaxes NK Cell-Mediated Tumor Surveillance
por: Putz, Eva Maria, et al.
Publicado: (2014)

A Recurrent STAT5B(N642H) Driver Mutation in Feline Alimentary T Cell Lymphoma
por: Kieslinger, Matthias, et al.
Publicado: (2021)

Cell Metabolism Control Through O-GlcNAcylation of STAT5: A Full or Empty Fuel Tank Makes a Big Difference for Cancer Cell Growth and Survival
por: Rauth, Manuel, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_gpnr64e0eq2nv1jokf8j0qjgr8