An essential pathway links FLT3-ITD, HCK and CDK6 in acute myeloid leukemia

CDK4/CDK6 and RB proteins drive the progression through the G1 phase of the cell cycle. In acute myeloid leukemia (AML), the activity of the CDK/Cyclin D complex is increased. The mechanism involved is unknown, as are the respective roles played by CDK4 or CDK6 in this process. Here, we report that...

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Detalles Bibliográficos
Autores principales: Lopez, Sophie, Voisset, Edwige, Tisserand, Julie C., Mosca, Cyndie, Prebet, Thomas, Santamaria, David, Dubreuil, Patrice, Sepulveda, Paulo De
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239466/
https://www.ncbi.nlm.nih.gov/pubmed/27323399
http://dx.doi.org/10.18632/oncotarget.9965

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