Biguanides sensitize leukemia cells to ABT-737-induced apoptosis by inhibiting mitochondrial electron transport

Metformin displays antileukemic effects partly due to activation of AMPK and subsequent inhibition of mTOR signaling. Nevertheless, Metformin also inhibits mitochondrial electron transport at complex I in an AMPK-independent manner, Here we report that Metformin and rotenone inhibit mitochondrial el...

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Detalles Bibliográficos
Autores principales: Velez, Juliana, Pan, Rongqing, Lee, Jason T.C., Enciso, Leonardo, Suarez, Marta, Duque, Jorge Eduardo, Jaramillo, Daniel, Lopez, Catalina, Morales, Ludis, Bornmann, William, Konopleva, Marina, Krystal, Gerald, Andreeff, Michael, Samudio, Ismael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239486/
https://www.ncbi.nlm.nih.gov/pubmed/27283492
http://dx.doi.org/10.18632/oncotarget.9843

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